ArticleCancer letters2010
Wnt signaling can substitute for estrogen to induce division of ERalpha-positive cells in a mouse mammary tumor model.
Article in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status.Open life sciences · 2025Article
- Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.OncoTargets and therapy · 2020Article
- miR-190 enhances endocrine therapy sensitivity by regulating SOX9 expression in breast cancer.Journal of experimental & clinical cancer research : CR · 2019Article
- Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers.PLoS genetics · 2018Article
- Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.Breast cancer research : BCR · 2017Article
- Deciphering the divergent roles of progestogens in breast cancer.Nature reviews. Cancer · 2017Review
- Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.Nature cell biology · 2016Article
- Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial Cells.Molecular and cellular biology · 2015Article
- Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.Journal of mammary gland biology and neoplasia · 2015Review
- ERrrr…where are the progenitors? Hormone receptors and mammary cell heterogeneity.Journal of mammary gland biology and neoplasia · 2015Review
- Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy.Journal of mammary gland biology and neoplasia · 2015Review
- Transcriptome analysis of the hormone-sensing cells in mammary epithelial reveals dynamic changes in early pregnancy.BMC developmental biology · 2015Article
- Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.PloS one · 2014Article
- Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling.PloS one · 2012Article
- A phenotypic mouse model of basaloid breast tumors.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The interaction of estrogen with the estrogen receptor (ER, principally ERalpha) induces growth of human breast tumor cells. In contrast, ERalpha-positive cells have been described as non-dividing cells in normal breast (though estrogen stimulation of ERalpha cells directs the division of neighboring cells). However, there is a small sub-population of cells in normal mammary tissue that are ERalpha-positive, that can divide, and therefore share this property with human breast tumor cells. In order to investigate their pattern of growth regulation, we measured the fraction of dividing ERalpha(+) cells during normal growth and compared that to glands stimulated by oncogenic Wnt effectors. First, we found there was no difference between the rate of division of ERalpha(+) cells and ERalpha(-) cells, whether the population was responding to estrogen or Wnt mitogens. The proportion of dividing ERalpha(+) mammary epithelial cells was increased (10x) in response to pregnancy, and similar increases were observed in response to ectopic Wnt signaling. We propose that Wnt signaling can substitute for estrogen to drive total population growth (that includes ERalpha(+) cells). Although the E-ERalpha-derived mitogenic response is situated in a minority of the luminal cells, and the Wnt-LRP5/6-derived mitogenic response is situated in a minority of basal cells, overall, the growth response of the mammary epithelial population is remarkably similar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.