ReviewRespiratory physiology & neurobiology2009
Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury.
Review in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Neuroprotective effects of P7C3 against spinal cord injury in rats.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury.Frontiers in neuroscience · 2019Article
- Transplantation of PDGF-AA-Overexpressing Oligodendrocyte Precursor Cells Promotes Recovery in Rat Following Spinal Cord Injury.Frontiers in cellular neuroscience · 2017Article
- Transplantation of Hematopoietic Stem Cells Promotes Functional Improvement Associated with NT-3-MEK-1 Activation in Spinal Cord-Transected Rats.Frontiers in cellular neuroscience · 2017Article
- Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation.Clinical and translational medicine · 2016Review
- Genetically modified human umbilical cord blood cells as a promising strategy for treatment of spinal cord injury.Neural regeneration research · 2016Article
- Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers.Shock (Augusta, Ga.) · 2015Review
- Schwann cells induce Proliferation and Migration of Oligodendrocyte Precursor Cells Through Secretion of PDGF-AA and FGF-2.Journal of molecular neuroscience : MN · 2015Article
- Long-term survival, axonal growth-promotion, and myelination of Schwann cells grafted into contused spinal cord in adult rats.Experimental neurology · 2014Article
- A novel growth-promoting pathway formed by GDNF-overexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Regenerative medicine for the treatment of spinal cord injury: more than just promises?Journal of cellular and molecular medicine · 2012Review
- Breaking news in spinal cord injury research: FDA approved phase I clinical trial of human, autologous schwann cell transplantation in patients with spinal cord injuries.Neural regeneration research · 2012Article
- Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Article
- Construction of pathways to promote axon growth within the adult central nervous system.Brain research bulletin · 2011Review
- Horizontal ladder task-specific re-training in adult rats with contusive thoracic spinal cord injury.Restorative neurology and neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Devastating central nervous system injuries and diseases continue to occur in spite of the tremendous efforts of various prevention programs. The enormity and annual escalation of healthcare costs due to them require that therapeutic strategies be responsibly developed. The dysfunctions that occur after injury and disease are primarily due to neurotransmission damage. The last two decades of both experimental and clinical research have demonstrated that neural and non-neural tissue and cell transplantation is a viable option for ameliorating dysfunctions to markedly improve quality of life. Moreover, significant progress has been made with tissue and cell transplantation in studies of pathophysiology, plasticity, sprouting, regeneration, and functional recovery. This article will review information about the ability and potential, particularly for traumatic spinal cord injury, that neural and non-neural tissue and cell transplantation has to replace lost neurons and glia, to reconstruct damaged neural circuitry, and to restore neurotransmitters, hormones, neurotrophic factors, and neurotransmission. Donor tissues and cells to be discussed include peripheral nerve, fetal spinal cord and brain, central and peripheral nervous systems' glia, stem cells, those that have been genetically engineered, and non-neural ones. Combinatorial approaches and clinical research are also reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.