ArticleMethods (San Diego, Calif.)2010
Development of structural MR brain imaging protocols to study genetics and maturation.
Article in Methods (San Diego, Calif.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.Human brain mapping · 2024Article
- White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development.Journal of neuroscience methods · 2024Article
- Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation.PLoS pathogens · 2022Article
- Article
- Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data.Frontiers in neuroinformatics · 2019Article
- Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Frontiers in neuroscience · 2017Article
- A voxel-based morphometric study of age- and sex-related changes in white matter volume in the normal aging brain.Neuropsychiatric disease and treatment · 2016Article
- Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Multi-region hemispheric specialization differentiates human from nonhuman primate brain function.Brain structure & function · 2014Article
- Article
- Hyperglycemic Challenge and Distribution of Adipose Tissue in Obese Baboons.International journal of diabetology & vascular disease research · 2014Article
- Genetic contributions to the midsagittal area of the corpus callosum.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
- A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex.Neuroinformatics · 2012Article
- Fractional anisotropy of cerebral white matter and thickness of cortical gray matter across the lifespan.NeuroImage · 2011Article
- Multi-parametric neuroimaging reproducibility: a 3-T resource study.NeuroImage · 2011Article
- Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.Frontiers in neuroscience · 2011Article
- MRI of perfusion-diffusion mismatch in non-human primate (baboon) stroke: a preliminary report.The open neuroimaging journal · 2011Article
- Tracking development of the corpus callosum in fetal and early postnatal baboons using magnetic resonance imaging.The open neuroimaging journal · 2011Article
- Atlas-guided segmentation of vervet monkey brain MRI.The open neuroimaging journal · 2011Article
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2 authors.
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Abstract
Structural imaging research offers excellent translational benefits when non-human primate (NHP) models are employed. In this paper, we will discuss the development of anatomical MR imaging protocols for two important applications of structural imaging in NHPs: studies of genetic variability in brain morphology and longitudinal imaging of fetal brain maturation trends. In contrast with imaging studies of adult humans, structural imaging in the NHPs is challenging due to a comparatively small brain size (2- to 200-fold smaller volume, depending on the species). This difference in size is further accentuated in NHP studies of brain development in which fetal brain volumes are 10-50% of their adult size. The sizes of cortical gyri and sulci scale allometrically with brain size. Thus, achieving spatial sampling that is comparable to that of high-quality human studies (approximately 1.0 mm(3)) requires a brain-size-adjusted reduction in the sampling volumes of from 500-to-150 microm(3). Imaging at this spatial resolution while maintaining sufficient contrast and signal to noise ratio necessitates the development of specialized MRI protocols. Here we discuss our strategy to optimize the protocol parameters for two commonly available structural imaging sequences: MPRAGE and TrueFisp. In addition, computational tools developed for the analysis of human structural images were applied to the NHP studies. These included removal of non-brain tissues, correction for RF inhomogeneity, spatial normalization, building of optimized target brain and analysis of cerebral gyrification and individual cortical variability. Finally, recent findings in the genetics of cerebral gyrification and tracking of maturation trends in the fetal, newborn and adult brain are described.
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