Evidence map›Paper›PMID 19664690›Full record

ReviewBiochimica et biophysica acta2009

Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.

Kate Petersen Shay, Régis F Moreau, Eric J Smith, Anthony R Smith, Tory M Hagen

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 345 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
345citing papers in PubMed, 3 pooled it
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221350 nacompletednot on this mapstarted 2010, after this paper: background citation

Exploratory Study of Lipoic Acid Supplementation on Oxidative Stress, Inflammatory and Functional Markers in Asthmatic Patients: Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.

TypeinterventionalSponsorCentro Universitario de Ciencias de la Salud, MexicoRan2010 to 2012Enrolled55ConditionsAsthma, Allergic RhinitisArmsLipoic acid, Placebo
NCT03952533 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of the Supplementation of α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D to Women Presenting Risk Factor for Pre-term Birth

TypeinterventionalSponsorUniversity of Modena and Reggio EmiliaRan2019 to 2021Enrolled122ConditionsCervical Shortening, Preterm BirthArmsDav
NCT04881851 naterminatednot on this mapstarted 2015, after this paper: background citation

Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment

TypeinterventionalSponsorUniversita di VeronaRan2015 to 2025Enrolled76ConditionsPolycystic Ovary SyndromeArmsInositol + alpha lipoic acid, Inositol, Folic acid (placebo comparator)
3 · Its place in the literature

Who cites it

345 citing papers in PubMed, 3 syntheses or guidelines pooled it, 958 citations in OpenAlex.

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285 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kate Petersen ShayLinus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA.
Régis F Moreau
Eric J Smith
Anthony R Smith
Tory M Hagen
Oregon State University · US

Funding

Overall Program/FreiP01AT002034 · NCCIH · OREGON STATE UNIVERSITY · PI FREI, BALZ B · 2003 to 2012
$11.7M
NCCIH NIH HHS P01 AT002034
6 · The paper itself

Abstract

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. How do the biochemical properties of LA relate to its biological effects? Herein, we review the molecular mechanisms of LA discovered using cell and animal models, and the effects of LA on human subjects. Though LA has long been touted as an antioxidant, it has also been shown to improve glucose and ascorbate handling, increase eNOS activity, activate Phase II detoxification via the transcription factor Nrf2, and lower expression of MMP-9 and VCAM-1 through repression of NF-kappa B. LA and its reduced form, dihydrolipoic acid, may use their chemical properties as a redox couple to alter protein conformations by forming mixed disulfides. Beneficial effects are achieved with low micromolar levels of LA, suggesting that some of its therapeutic potential extends beyond the strict definition of an antioxidant. Current trials are investigating whether these beneficial properties of LA make it an appropriate treatment not just for diabetes, but also for the prevention of vascular disease, hypertension, and inflammation.

Indexed as

Dietary SupplementsAnimalsDiabetic NeuropathiesHumansHypertensionInflammationModels, BiologicalMolecular StructureThioctic AcidVascular DiseasesThioctic Acid

Identifiers

PMID19664690
PMCPMC2756298
OpenAlexW2156813826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.