ArticleHealth and quality of life outcomes2009
Utility of WHOQOL-BREF in measuring quality of life in sickle cell disease.
Article in Health and quality of life outcomes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04810572 (Evaluation of the Effects of a Nutraceutical Composition Containing Derivatives From Natural Products on the Modulation of the Endocrine Neuroimmune Axis - Translational Study.), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of a Nutraceutical Composition Containing Derivatives From Natural Products on the Modulation of the Endocrine Neuroimmune Axis - Translational Study.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Self-reported perspective in rare genetic diseases: a systematic review of patient-reported outcome measures classified using the international classification of functioning, disability and health framework.Journal of patient-reported outcomes · 2026Pooled it
- Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective.Frontiers in pediatrics · 2022Pooled it
- Interventions for treating leg ulcers in people with sickle cell disease.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions for treating leg ulcers in people with sickle cell disease.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- WHOQOL-BREF in Measuring Quality of Life Among Sickle Cell Disease Patients with Leg Ulcers.International journal of environmental research and public health · 2025Article
- An Updated Analysis of the Impact of HPV Vaccination Based on Long-term Effectiveness in the Netherlands.Infectious diseases and therapy · 2023Article
- Quality of life among Syrian refugees in Germany: a cross-sectional pilot study.Archives of public health = Archives belges de sante publique · 2021Article
- Quality of Life and Factors Affecting It: A Study Among People Living Near a Solid Waste Management Facility.Frontiers in public health · 2021Article
- External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.PloS one · 2021Article
- Assessment of quality of life in individuals with chronic headache. Psychometric properties of the WHOQOL-BREF.BMC neurology · 2020Article
- Use of a Modified DANP-mV Model to Improve Quality of Life in Rural Residents: The Empirical Case of Xingshisi Village, China.International journal of environmental research and public health · 2019Article
- Tooth loss and general quality of life in dentate adults from Southern Brazil.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Difference in quality of life and associated factors among the elderly in rural Vietnam.Journal of preventive medicine and hygiene · 2017Article
- Application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with cataract.Epidemiology and health · 2016Article
- SF-36 total score as a single measure of health-related quality of life: Scoping review.SAGE open medicine · 2016Article
- Adult sickle cell quality-of-life measurement information system (ASCQ-Me): conceptual model based on review of the literature and formative research.The Clinical journal of pain · 2014Article
- Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy.Clinical rheumatology · 2014Observational
- Poor health related quality of life among patients of sickle cell disease.Indian journal of palliative care · 2014Article
- Application of WHOQOL-BREF in Measuring Quality of Life in Health-Care Staff.International journal of preventive medicine · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell disease is the commonest genetic disorder in Jamaica and most likely exerts numerous effects on quality of life (QOL) of those afflicted with it. The WHOQOL-Bref, which is a commonly utilized generic measure of quality of life, has never previously been utilized in this population. We have sought to study its utility in this disease population.
methods491 patients with sickle cell disease were administered the questionnaire including demographics, WHOQOL-Bref, Short Form-36 (SF-36), Flanagan's quality of life scale (QOLS) and measures of disease severity at their routine health maintenance visits to the sickle cell unit. Internal consistency reliabilities, construct validity and "known groups" validity of the WHOQOL-Bref, and its domains, were examined; and then compared to those of the other instruments.
resultsAll three instruments had good internal consistency, ranging from 0.70 to 0.93 for the WHOQOL-Bref (except the 'social relationships' domain), 0.86-0.93 for the SF-36 and 0.88 for the QOLS. None of the instruments showed any marked floor or ceiling effects except the SF-36 'physical health' and 'role limitations' domains. The WHOQOL-Bref scale also had moderate concurrent validity and showed strong "known groups" validity.
conclusionThis study has shown good psychometric properties of the WHOQOL-Bref instrument in determining QOL of those with sickle cell disease. Its utility in this regard is comparable to that of the SF-36 and QOLS.
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