ReviewCritical care (London, England)2009
Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials.
Review in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02657109 (Influence of Early Mobilization Protocol in Heart Valve Replacement on Heart Rate Variability and Oxidative Stress), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Early Mobilization Protocol in Heart Valve Replacement on Heart Rate Variability and Oxidative Stress
Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review.Intensive care medicine · 2017Pooled it
- Practical guidelines: lung transplantation in patients with cystic fibrosis.Pulmonary medicine · 2014Guideline
- Pooled it
- Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review.BMC medicine · 2013Pooled it
- Safety of neuromuscular electrical stimulation among critically ill patients: systematic review.Revista Brasileira de terapia intensivaPooled it
- Effect of Early Postoperative Mobilization on Functional Recovery, Hospital Length of Stay, and Postoperative Complications After Immediate Internal Pudendal Artery Perforator Flap Reconstruction for Irradiated Abdominoperineal Resection Defects: A Prospective, Randomized Controlled Trial.Annals of surgical oncology · 2025Trial
- Effectiveness of early cardiac rehabilitation in patients with heart valve surgery: a randomized, controlled trial.The Journal of international medical research · 2022Trial
- Effects of Lung Expansion Therapy on Lung Function in Patients with Prolonged Mechanical Ventilation.Canadian respiratory journal · 2016Trial
- Trial
- Neuromuscular electrical stimulation for intensive care unit-acquired weakness: protocol and methodological implications for a randomized, sham-controlled, phase II trial.Physical therapy · 2012Trial
- Safety of Protocolized Motorized Verticalization in Critically Ill Patients With Impaired Consciousness and Invasive Devices, Including External Ventricular Drains.Critical care explorations · 2026Article
- Barriers to Mobility in the ICU: Insights from Severe COVID-19 and Implications for Improving Patient Outcomes.Archives of rehabilitation research and clinical translation · 2025Article
- Medium-Frequency Neuromuscular Electrical Stimulation in Critically Ill Patients Promoted Larger Functional Capacity Improvement During Recovery than Low-Frequency Neuromuscular Electrical Stimulation: Randomized Clinical Trial.Journal of clinical medicine · 2025Article
- Rehabilitation needs, preferences, barriers, and facilitators of individuals with sepsis: a qualitative study.International journal of nursing studies advances · 2025Article
- Long-Term Quality of Life Among Intensive Care Units Survivors.Risk management and healthcare policy · 2025Article
- Optimizing Early Recovery Through Timely Mobilization in Nephrectomy Patients: A Case Report.Cureus · 2024Article
- A Review of Hyperglycemia in COVID-19.Cureus · 2023Review
- Clinical and Epidemiological Characteristics of Patients with COVID-19 Admitted to the Intensive Care Unit: A Two-Year Retrospective Analysis.Life (Basel, Switzerland) · 2023Article
- Development and validation of an intensive care unit acquired weakness prediction model: A cohort study.Frontiers in medicine · 2023Article
- THE EFFECT OF IN-BED LEG CYCLING EXERCISES ON MUSCLE STRENGTH IN PATIENTS WITH INTENSIVE CARE UNIT-ACQUIRED WEAKNESS: A SINGLE-CENTER RETROSPECTIVE STUDY.Journal of rehabilitation medicine. Clinical communications · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the mortality from critical illness has improved in recent years, there has been increasing focus on patient outcomes after hospital discharge. Neuromuscular weakness acquired in the intensive care unit (ICU) is common, persistent, and often severe. Immobility due to prolonged bed rest in the ICU may play an important role in the development of ICU-acquired weakness. Studies in other patient populations have demonstrated that moderate exercise is beneficial in altering the inflammatory milieu associated with immobility, and in improving muscle strength and physical function. Recent studies have demonstrated that early mobility in the ICU is safe and feasible, with a potential reduction in short-term physical impairment. However, early mobility requires a significant change in ICU practice, with reductions in heavy sedation and bed rest. Further research is required to determine whether early mobility in the ICU can improve patients' short-term and long-term outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.