ArticleAge (Dordrecht, Netherlands)2010
Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.
Article in Age (Dordrecht, Netherlands), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Combinatorial interventions in aging.Nature aging · 2023Review
- Genomic signatures of thermal adaptation are associated with clinal shifts of life history in a broadly distributed frog.The Journal of animal ecology · 2022Article
- Mitochondria-derived peptides in aging and healthspan.The Journal of clinical investigation · 2022Review
- Biological age and environmental risk factors for dementia and stroke: Molecular mechanisms.Frontiers in aging neuroscience · 2022Review
- Identification of key pathways and metabolic fingerprints of longevity in C. elegans.Experimental gerontology · 2018Article
- Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan inInternational journal of molecular sciences · 2018Article
- Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.Current neurobiology · 2018Article
- Article
- The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.Oxidative medicine and cellular longevity · 2017Review
- Article
- Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.PLoS neglected tropical diseases · 2016Article
- Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway.Age (Dordrecht, Netherlands) · 2016Article
- Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.PLoS genetics · 2015Article
- Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2013Article
- Effect of temperature on the rate of ageing: an experimental study of the blowfly Calliphora stygia.PloS one · 2013Article
- Early cohort mortality predicts the rate of aging in the cohort: a historical analysis.Journal of developmental origins of health and disease · 2012Article
- FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.PloS one · 2011Article
- Mitochondrial uncoupling and lifespan.Mechanisms of ageing and developmentReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold temperature, dietary restriction, reduced insulin/insulin-like growth factor signaling, and mutations in mitochondrial genes have all been shown to extend the lifespan of Caenorhabditis elegans (Kenyon et al., Nature 366:461-464, 1993; Klass, Mech Ageing Dev 6:413-429, 1977; Lakowski and Hekimi, Science 272:1010-1013, 1996). Additionally, all of them extend the lifespan of mice (Bluher et al., Science 299:572-574, 2003; Conti et al., Science 314:825-828, 2006; Holzenberger et al., Nature 421:182-187, 2003; Liu et al., Genes Dev 19:2424-2434, 2005; Weindruch and Walford, Science 215:1415-1418, 1982). The mechanism by which these treatments extend lifespan is currently unknown, but our study uses an epistatic approach to show that these four manipulations are mainly additive in terms of lifespan. Classical interpretation of this data suggests that these manipulations are independent of each other. However, using a Gompertz mortality rate analysis, the maximum mortality rate doubling time can be achieved through the use of only dietary restriction and cold temperature, suggesting that the mechanisms by which cold temperature and caloric restriction extend lifespan are the only independent mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.