ArticleMolecular biology reports2010
Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Genetic Contribution of Polymorphisms in Glutathione S-Transferases to Brain Tumor Risk.Molecular neurobiology · 2016Pooled it
- Glutathione S-transferase M1, T1, and P1 polymorphisms and risk of glioma: a meta-analysis.Molecular biology reports · 2013Pooled it
- Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.PloS one · 2012Pooled it
- Genetic polymorphisms of glutathione S-transferase M1 and bladder cancer risk: a meta-analysis of 26 studies.Molecular biology reports · 2011Pooled it
- Association of Glutathione S-TransferaseReports of biochemistry & molecular biology · 2020Article
- Article
- The association between GSTT1, M1, and P1 polymorphisms with coronary artery disease in Western Iran.Molecular and cellular biochemistry · 2011Article
- Lack of association between GSTT1 polymorphism and endogenous or benzo[a]pyrene-induced sister chromatid exchanges as analyzed in metaphase or G2-phase lymphocytes.Molecular biology reports · 2011Article
- Serum testosterone in females exposed to natural sour gas with respect to polymorphisms of XRCC1, GSTM1, and GSTT1.Molecular biology reports · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To find the influence of genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) on hematological parameters in smoker and non-smoker subjects, the present study was done. This cross-sectional study was conducted on 97 healthy males (24 smokers, 73 non-smokers). The genotypes were determined using a polymerase chain reaction based method. In non-smokers, there was no statistically association between number of active genes and the study parameters. However, in smokers, RBC count was significantly decreased in null genotypes of GSTT1 (t = 3.021, df = 22, P = 0.006) and GSTM1 (t = 2.141, df = 22, P = 0.044). Also, in smokers, RBC count significantly decreased in persons having GSTM1 and GSTT1 null genotypes in comparison with subjects having two active genes (F = 5.554; df = 2, 21; P = 0.012). Because elevated RBC count correlate well with risk of coronary heart disease, it might be concluded that GSTM1 and GSTT1 null genotypes have protective role(s) for developing coronary heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.