ArticleMolecular biology reports2010
A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Integrated transcriptomic and metabolomic analyses reveal the regulatory mechanism of subcutaneous fat deposition in Baicheng Oil chickens.Poultry science · 2026Article
- Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.Animals : an open access journal from MDPI · 2023Article
- Relationships of genomic estimated breeding values for age at puberty, birth weight, and growth during development in normal cyclic and acyclic gilts.Journal of animal science · 2023Article
- Using genome wide association studies to identify common QTL regions in three different genetic backgrounds based on Iberian pig breed.PloS one · 2018Article
- Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed.Molecular biology reports · 2016Article
- Developmental changes and effect on intramuscular fat content of H-FABP and A-FABP mRNA expression in pigs.Journal of applied genetics · 2013Article
- Genome-wide linkage analysis of QTL for growth and body composition employing the PorcineSNP60 BeadChip.BMC genetics · 2012Article
- Association between polymorphisms in cathepsin and cystatin genes with meat production and carcass traits in Italian Duroc pigs: confirmation of the effects of a cathepsin L (CTSL) gene marker.Molecular biology reports · 2012Article
- The porcine TBC1D1 gene: mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigs.Molecular biology reports · 2011Article
- Identification of three novel SNPs and association with carcass traits in porcine TNNI1 and TNNI2.Molecular biology reports · 2010Article
- Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs.Molecular biology reports · 2010Article
- Genetics of fat tissue accumulation in pigs: a comparative approach.Journal of applied genetics · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cathepsin K (CTSK) was selected as a candidate gene for fat deposition in pigs because recently, in human and mouse, it was shown that this lysosomal proteinase is an obesity marker. A single nucleotide polymorphism (SNP) was identified in intron 4 of the porcine CTSK gene (g.15G>A; FM209043). Allele frequencies of this polymorphism were analysed in seven pig breeds. Radiation hybrid mapping confirmed the localization of CTSK to porcine chromosome 4, close to the FAT1 QTL region. Three populations of pigs (one Italian Large White and two Italian Duroc groups of pigs) were selected for association analysis. In the Italian Large White breed the g.15G>A SNP was not informative. Association analysis including all Italian Duroc pigs showed that the CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.
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