Evidence map›Paper›PMID 19662494›Full record

ReviewIrish journal of medical science2010

Anaplastic thyroid cancer, tumorigenesis and therapy.

J P O'Neill, D Power, C Condron, D Bouchier-Hayes, M Walsh

Abstract readReview
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In one paragraph

Review in Irish journal of medical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Anaplastic thyroid carcinoma.Frontiers in endocrinology · 2012
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J P O'NeillThe Department of Otolaryngology, The Royal College of Surgeons in Ireland, Beaumont Hospital, The Education and Research Building, Beaumont, Dublin 9, Ireland. joneill@rcsi.ie
D Power
C Condron
D Bouchier-Hayes
M Walsh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies.

methodsAn extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings.

conclusionsSignificant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.

Indexed as

Antineoplastic Agentsbeta CateninCadherinsCyclinsDisease ProgressionErbB ReceptorsHumansRadiotherapyThyroid NeoplasmsVascular Endothelial Growth Factor AAntineoplastic Agentsbeta CateninCadherinsCyclinsErbB ReceptorsVascular Endothelial Growth Factor A

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.