Evidence map›Paper›PMID 19662331›Full record

ArticleClinical rheumatology2009

Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians.

Dejan Trajkov, Snezhana Mishevska-Perchinkova, Anzelika Karadzova-Stojanoska, Aleksandar Petlichkovski, Ana Strezova, Mirko Spiroski

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 9 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 9 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  8. The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
    Pooled it
  9. Pooled it
  10. Trial
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Promoter polymorphism (-590, T/C) of interleukin 4 (Saudi journal of biological sciences · 2017
    Review
  17. A posteriori evaluation of effects attributed to IL-6 gene regulatory variants.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dejan TrajkovInstitute of Immunobiology and Human Genetics, University Ss. Kiril and Metodij, 1109, Skopje, P.O. Box 60, Republic of Macedonia.
Snezhana Mishevska-Perchinkova
Anzelika Karadzova-Stojanoska
Aleksandar Petlichkovski
Ana Strezova
Mirko Spiroski
University Clinic of Traumatology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against RA in Macedonians. In this study, 301 healthy unrelated individuals and 85 patients with RA were studied. Cytokine genotyping was performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit). Results showed susceptible association for four cytokine alleles, six cytokine genotypes, one haplotype, and four combinations of haplotypes, while protective associations were found for four cytokine alleles, three cytokine genotypes, three haplotypes, and only one combination of haplotypes. These results suggest that IL-4 -1098, IL-4 -590, IL-10 -1082, IL-10 -819, IL-2 -330, IL-6 -174, and TNF-alpha -238 cytokine gene polymorphisms might be significantly associated and affect host susceptibility and/or resistance to RA in Macedonians.

Indexed as

Arthritis, RheumatoidEthnicityGenetic Predisposition to DiseasePolymorphism, Single NucleotideHaplotypesHumansInterleukinsRepublic of North MacedoniaTumor Necrosis Factor-alphaInterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID19662331
OpenAlexW1983986500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.