Trial reportStroke2009
Brief psychosocial-behavioral intervention with antidepressant reduces poststroke depression significantly more than usual care with antidepressant: living well with stroke: randomized, controlled trial.
Trial report in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01133106 (Psychosocial/Behavioral Intervention in Post-Stroke Depression), which is not on this map. Cited by 54 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychosocial/Behavioral Intervention in Post-Stroke Depression (PSD)
Who cites it
54 citing papers in PubMed, 11 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- A rapid realist review of clinical neuropsychology rehabilitation programmes to improve psychological wellbeing and quality of life for people with acquired brain injuries.Neuropsychological rehabilitation · 2024Pooled it
- Pharmacological, non-invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke.The Cochrane database of systematic reviews · 2023Pooled it
- Effectiveness of non-pharmacological interventions for treating post-stroke depressive symptoms: Systematic review and meta-analysis of randomized controlled trials.Topics in stroke rehabilitation · 2021Pooled it
- Efficacy of repetitive transcranial magnetic stimulation for post-stroke depression: a systematic review and meta-analysis of randomized clinical trials.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- Behavioural activation therapy for depression in adults with non-communicable diseases.The Cochrane database of systematic reviews · 2020Pooled it
- Pharmacological, psychological, and non-invasive brain stimulation interventions for treating depression after stroke.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for Psychological Health of Stroke Caregivers: A Systematic Review.Frontiers in psychology · 2019Pooled it
- Motivational interviewing for improving recovery after stroke.The Cochrane database of systematic reviews · 2015Pooled it
- Behavioural activation for depression; an update of meta-analysis of effectiveness and sub group analysis.PloS one · 2014Pooled it
- Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery.The Cochrane database of systematic reviews · 2012Pooled it
- Early emotional interventions for post-stroke functional prognosis: a systematic review and meta-analysis.Frontiers in neurologyPooled it
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- Intensive Communicative Therapy Reduces Symptoms of Depression in Chronic Nonfluent Aphasia.Neurorehabilitation and neural repair · 2017Trial
- Randomized trial of telephone versus in-person delivery of a brief psychosocial intervention in post-stroke depression.BMC research notes · 2017Trial
- Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial.BMC public health · 2017Trial
- Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia.Clinical rehabilitation · 2013Trial
- Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms.Stroke · 2011Trial
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeDepression after stroke is prevalent, diminishing recovery and quality of life. Brief behavioral intervention, adjunctive to antidepressant therapy, has not been well evaluated for long-term efficacy in those with poststroke depression.
methodsOne hundred one clinically depressed patients with ischemic stroke within 4 months of index stroke were randomly assigned to an 8-week brief psychosocial-behavioral intervention plus antidepressant or usual care, including antidepressant. The primary end point was reduction in depressive symptom severity at 12 months after entry.
resultsHamilton Rating Scale for Depression raw score in the intervention group was significantly lower immediately posttreatment (P<0.001) and at 12 months (P=0.05) compared with control subjects. Remission (Hamilton Rating Scale for Depression <10) was significantly greater immediately posttreatment and at 12 months in the intervention group compared with the usual care control. The mean percent decrease (47%+/-26% intervention versus 32%+/-36% control, P=0.02) and the mean absolute decrease (-9.2+/-5.7 intervention versus -6.2+/-6.4 control, P=0.023) in Hamilton Rating Scale for Depression at 12 months were clinically important and statistically significant in the intervention group compared with control.
conclusionsA brief psychosocial-behavioral intervention is highly effective in reducing depression in both the short and long term.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.