ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Recent approaches in the sensing strategy for the detection of cardiovascular disease biomarkers.RSC advances · 2026Review
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques.ACS biomaterials science & engineering · 2025Article
- Oxygen-binding proteins aid oxygen diffusion to enhance fitness of a yeast model of multicellularity.PLoS biology · 2025Article
- Type 2 diabetes-related sarcopenia: role of nitric oxide.Nutrition & metabolism · 2024Review
- Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques.bioRxiv : the preprint server for biology · 2024Article
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin.Physiological reviews · 2024Review
- A short review of application of near-infrared spectroscopy (NIRS) for the assessment of microvascular post-occlusive reactive hyperaemia (PORH) in skeletal muscle.Frontiers in physiology · 2024Review
- Examining the role of oxygen-binding proteins on the early evolution of multicellularity.bioRxiv : the preprint server for biology · 2023Article
- Low myoglobin concentration in skeletal muscle of elite cyclists is associated with low mRNA expression levels.European journal of applied physiology · 2023Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Under the Hood: Skeletal Muscle Determinants of Endurance Performance.Frontiers in sports and active living · 2021Review
- Transcapillary POThe Journal of physiology · 2020Article
- In vivo photoacoustic tomography of myoglobin oxygen saturation.Journal of biomedical optics · 2016Article
- Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.Free radical biology & medicine · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine the myoglobin concentration in skeletal muscle fibers of chronic heart failure (CHF) patients and to calculate the effect of myoglobin on oxygen buffering and facilitated diffusion. Myoglobin concentration, succinate dehydrogenase (SDH) activity, and cross-sectional area of individual muscle fibers from the vastus lateralis of five control and nine CHF patients were determined using calibrated histochemistry. CHF patients compared with control subjects were similar with respect to myoglobin concentration: type I fibers 0.69 +/- 0.11 mM (mean +/- SD), type II fibers 0.52 +/- 0.07 mM in CHF vs. type I fibers 0.70 +/- 0.09 mM, type II fibers 0.49 +/- 0.07 mM in control, whereas SDH activity was significantly lower in CHF in both fiber types (P < 0.01). The myoglobin concentration in type I fibers was higher than in type II fibers (P < 0.01). Consequently, the oxygen buffering capacity, calculated from myoglobin concentration/SDH activity was increased in CHF: type I fibers 11.4 +/- 2.1 s, type II fibers 13.6 +/- 3.9 s in CHF vs. type I fibers 7.8 +/- 0.9 s, type II fibers 7.5 +/- 1.0 s in control, all P < 0.01). The calculated extracellular oxygen tension required to prevent core anoxia (Po2(crit)) in muscle fibers was similar when controls were compared with patients in type I fibers 10.3 +/- 0.9 Torr in CHF and 11.5 +/- 3.3 Torr in control, but was lower in type II fibers of patients 6.1 +/- 2.8 Torr in CHF and 14.7 +/- 6.2 Torr in control, P < 0.01. The lower Po2(crit) of type II fibers may facilitate oxygen extraction from capillaries. Reduced exercise tolerance in CHF is not due to myoglobin deficiency.
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