Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2009
Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Trial
- Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Sustained exercise hyperemia during prolonged adenosine infusion in humans.Physiological reports · 2019Article
- Inhibition of NaThe Journal of physiology · 2018Article
- Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system.American journal of physiology. Heart and circulatory physiology · 2017Article
- Skeletal muscle vasodilation during systemic hypoxia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Neural control of blood flow during exercise in human metabolic syndrome.Experimental physiology · 2014Article
- Individual susceptibility to hypoperfusion and reductions in exercise performance when perfusion pressure is reduced: evidence for vasodilator phenotypes.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Sex and vasodilator responses to hypoxia at rest and during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Muscle blood flow, hypoxia, and hypoperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise.European journal of applied physiology · 2013Article
- Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand.The Journal of physiology · 2012Review
- Ischemic exercise hyperemia in the human forearm: reproducibility and roles of adenosine and nitric oxide.European journal of applied physiology · 2012Article
- Local control of skeletal muscle blood flow during exercise: influence of available oxygen.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Augmented skeletal muscle hyperaemia during hypoxic exercise in humans is blunted by combined inhibition of nitric oxide and vasodilating prostaglandins.The Journal of physiology · 2011Article
- Hypoxia: just say NO?The Journal of physiology · 2011Article
- Hyperbaric hyperoxia reduces exercising forearm blood flow in humans.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We tested the hypothesis that adenosine contributes to augmented skeletal muscle vasodilation during hypoxic exercise. In separate protocols, subjects performed incremental rhythmic forearm exercise (10% and 20% of maximum) during normoxia and normocapnic hypoxia (80% arterial O2 saturation). In protocol 1 (n = 8), subjects received an intra-arterial administration of saline (control) and aminophylline (adenosine receptor antagonist). In protocol 2 (n = 10), subjects received intra-arterial phentolamine (alpha-adrenoceptor antagonist) and combined phentolamine and aminophylline administration. Forearm vascular conductance (FVC; in ml x min(-1).100 mmHg(-1)) was calculated from forearm blood flow (in ml/min) and blood pressure (in mmHg). In protocol 1, the change in FVC (DeltaFVC; change from normoxic baseline) during hypoxic exercise with saline was 172 +/- 29 and 314 +/- 34 ml x min(-1) x 100 mmHg(-1) (10% and 20%, respectively). Aminophylline administration did not affect DeltaFVC during hypoxic exercise at 10% (190 +/- 29 ml x min(-1)x100 mmHg(-1), P = 0.4) or 20% (287 +/- 48 ml x min(-1) x 100 mmHg(-1), P = 0.3). In protocol 2, DeltaFVC due to hypoxic exercise with phentolamine infusion was 313 +/- 30 and 453 +/- 41 ml x min(-1) x 100 mmHg(-1) (10% and 20% respectively). DeltaFVC was similar at 10% (352 +/- 39 ml min(-1) x 100 mmHg(-1), P = 0.8) and 20% (528 +/- 45 ml x min(-1) x 100 mmHg(-1), P = 0.2) hypoxic exercise with combined phentolamine and aminophylline. In contrast, DeltaFVC to exogenous adenosine was reduced by aminophylline administration in both protocols (P < 0.05 for both). These observations suggest that adenosine receptor activation is not obligatory for the augmented hyperemia during hypoxic exercise in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.