Trial reportPsychosomatic medicine2009
Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia.
Trial report in Psychosomatic medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Association of inflammation and cognition in the elderly: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Spousal caregiving, widowhood, and cognition: A systematic review and a biopsychosocial framework for understanding the relationship between interpersonal losses and dementia risk in older adulthood.Neuroscience and biobehavioral reviews · 2022Pooled it
- Biomarker advancements in cerebral small vessel disease: An overview.Neural regeneration research · 2026Article
- Executive function and soluble urokinase-type plasminogen activator receptor (suPAR): a longitudinal study of midlife adults.Brain, behavior, and immunity · 2025Article
- Cortical thickness and low-grade inflammation moderate the association between depressive symptoms and cognitive function in early widowhood: A preliminary study.Brain, behavior, and immunity · 2025Article
- The Effect of Statin Therapy on Hemorheological Parameters of Patients with Clinically Silent Ischemic Foci of the Brain.International journal of molecular sciences · 2025Article
- Cognitive functions in schizophrenia: the interplay between blood viscosity, serum osmolarity, and symptom severity.BMC psychiatry · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- Plasma fibrinogen as a potential biomarker of cognitive impairment after acute ischemic stroke.Scientific reports · 2024Article
- Repetitive thought, cognition, and systemic inflammation in the midlife in the United States study.Psychology & health · 2024Article
- Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).Brain, behavior, & immunity - health · 2024Article
- Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia.Frontiers in stroke · 2024Review
- Article
- Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization.Nature medicine · 2023Article
- High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study.Brain sciences · 2023Article
- Heterogeneity of White Matter Hyperintensity and Cognitive Impairment in Patients with Acute Lacunar Stroke.Brain sciences · 2022Article
- Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain.Journal of clinical medicine · 2022Article
- The Relationships of Fibrinogen and C-Reactive Protein With Gait Performance: A 20-Year Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- APOE - a genetic marker of comorbidity in subjects with morbid obesity.BMC medical genetics · 2020Article
- Relationship between fibrinogen level and its regulatory gene with Alzheimer's disease and vascular dementia.The Journal of international medical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people.
methodsSubjects consisted of 2312 men and women aged 50 to 80 years participating in the Aspirin for Asymptomatic Atherosclerosis Trial, all of whom were free of symptomatic cardiovascular disease at baseline. Biomarker levels and cognitive ability were measured at baseline with cognition assessed in all subjects using the Mill Hill Vocabulary Scale and in a subgroup of 504 persons using tests of memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. After 5 years, the five-test battery was administered to all participants and scores were used to derive a general cognitive ability factor.
resultsBaseline CRP and fibrinogen levels were associated negatively with age and sex-adjusted follow-up scores on the majority of the cognitive tests, and the general cognitive ability factor (correlations = -0.054 to 0.105, p < .05). In analyses adjusting for baseline cognitive scores, asymptomatic atherosclerotic disease, and cardiovascular risk factors, both markers predicted decline in several cognitive domains (excluding memory). Baseline plasma viscosity, but not hematocrit, was associated negatively with follow-up test scores for general cognitive ability, information processing speed, and mental flexibility (correlations = -0.050 to -0.098, p < .05) and with decline across the same domains (p < .05).
conclusionsIncreased circulating levels of CRP, fibrinogen, and elevated plasma viscosity predicted poorer subsequent cognitive ability and were associated with age-related cognitive decline in several domains, including general ability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.