ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Effects of electrical stimulation on isolated rodent gastric smooth muscle cells evaluated via a joint computational simulation and experimental approach.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Accelerated Electron Ionization-Induced Changes in the Myenteric Plexus of the Rat Stomach.International journal of molecular sciences · 2024Article
- Design of Bio-Optical Transceiver for In Vivo Biomedical Sensor Applications.Sensors (Basel, Switzerland) · 2024Article
- An efficient online peak detection algorithm for synchronized intestinal electrical stimulation and its application for treating diabetes.Medical & biological engineering & computing · 2023Article
- Engaging biological oscillators through second messenger pathways permits emergence of a robust gastric slow-wave during peristalsis.PLoS computational biology · 2021Article
- Gastric neurons in the nucleus tractus solitarius are selective to the orientation of gastric electrical stimulation.Journal of neural engineering · 2021Article
- Stomach region stimulated determines effects on duodenal motility in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study.Physiological reports · 2021Article
- Computational motility models of neurogastroenterology and neuromodulation.Brain research · 2018Review
- Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.Gastroenterology research and practice · 2018Article
- Nonparametric Model of Smooth Muscle Force Production During Electrical Stimulation.Journal of computational biology : a journal of computational molecular cell biology · 2017Article
- Pulse Width-Dependent Effects of Intestinal Electrical Stimulation for Obesity: Role of Gastrointestinal Motility and Hormones.Obesity surgery · 2017Article
- Acute Slow Wave Responses to High-Frequency Gastric Electrical Stimulation in Patients With Gastroparesis Defined by High-Resolution Mapping.Neuromodulation : journal of the International Neuromodulation Society · 2016Article
- Parameter selection and stimulating effects of an adjustable gastric electrical stimulator in dogs.Obesity surgery · 2014Article
- Mapping and modeling gastrointestinal bioelectricity: from engineering bench to bedside.Physiology (Bethesda, Md.) · 2013Review
- Food intake and body weight responses to intermittent vs. continuous gastric electrical stimulation in diet-induced obese rats.Obesity surgery · 2013Article
- Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT(2B) knockout mice with altered interstitial cells of Cajal networks.Biophysical journal · 2010Article
- High-resolution entrainment mapping of gastric pacing: a new analytical tool.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Multiscale modeling of gastrointestinal electrophysiology and experimental validation.Critical reviews in biomedical engineering · 2010Review
- A tissue framework for simulating the effects of gastric electrical stimulation and in vivo validation.IEEE transactions on bio-medical engineering · 2009Article
- The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Gastric electrical stimulation (GES) involves the delivery of electrical impulses to the stomach for therapeutic purposes. New GES protocols are needed that are optimized for improved motility outcomes and energy efficiency. In this study, a biophysically based smooth muscle cell (SMC) model was modified on the basis of experimental data and employed in conjunction with experimental studies to define the effects of a large range of GES protocols on individual SMCs. For the validation studies, rat gastric SMCs were isolated and subjected to patch-clamp analysis during stimulation. Experimental results were in satisfactory agreement with simulation results. The results define the effects of a wide range of GES parameters (pulse width, amplitude, and pulse-train frequency) on isolated SMCs. The minimum pulse width required to invoke a supramechanical threshold response from SMCs (defined at -30 mV) was 65 ms (at 250-pA amplitude). The minimum amplitude required to invoke this threshold was 75 pA (at 1,000-ms pulse width). The amplitude of the invoked response beyond this threshold was proportional to the stimulation amplitude. A high-frequency train of stimuli (40 Hz; 10 ms, 150 pA) could invoke and maintain the SMC plateau phase while requiring 60% less power and accruing approximately 30% less intracellular Ca(2+) concentration during the plateau phase than a comparable single-pulse protocol could in a demonstrated example. Validated computational simulations are an effective strategy for efficiently identifying effective minimum-energy GES protocols, and pulse-train protocols may also help to reduce the power consumption of future GES devices.
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