ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Modulation of the effect of prenatal PAH exposure on PAH-DNA adducts in cord blood by plasma antioxidants.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Role of antioxidant vitamins in mitigating the health risks from environmental toxicant exposures: a narrative review.Journal of the Endocrine Society · 2026Review
- The Interplay Between Nutrition and Stress in Pregnancy: Implications for Fetal Programming of Brain Development.Biological psychiatry · 2019Review
- Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months.Journal of developmental origins of health and disease · 2017Article
- Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea.Public health nutrition · 2016Article
- Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Seminars in cancer biology · 2015Review
- Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6-9.Environmental research · 2015Article
- Prenatal protection: maternal diet may modify impact of PAHs.Environmental health perspectives · 2013Article
- The relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts in cord blood.Journal of exposure science & environmental epidemiology · 2013Article
- The origins of health and disease: the influence of maternal diseases and lifestyle during gestation.Italian journal of pediatrics · 2013Review
- Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism.Environment international · 2012Article
- Impact of barbecued meat consumed in pregnancy on birth outcomes accounting for personal prenatal exposure to airborne polycyclic aromatic hydrocarbons: Birth cohort study in Poland.Nutrition (Burbank, Los Angeles County, Calif.) · 2012Article
- Environmental toxicants and the developing immune system: a missing link in the global battle against infectious disease?Reproductive toxicology (Elmsford, N.Y.) · 2011Review
- Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The fetus is more susceptible than the adult to the effects of certain carcinogens, such as polycyclic aromatic hydrocarbons (PAH). Nutritional factors, including antioxidants, have been shown to have a protective effect on carcinogen-DNA adducts and cancer risk in adults. We investigated whether the effect of prenatal airborne PAH exposure, measured by personal air monitoring during pregnancy, on the level of PAH-DNA adducts in a baby's cord blood is modified by the concentration of micronutrients in maternal and cord blood. The micronutrients examined were: retinol (vitamin A), alpha-tocopherol and gamma-tocopherol (vitamin E), and carotenoids. With the use of multiple linear regression, we found a significant interaction between prenatal PAH exposure and cord blood concentration of alpha-tocopherol and carotenoids in predicting the concentration of PAH adducts in cord blood. The association between PAH exposure and PAH adducts was much stronger among those with low alpha-tocopherol (beta = 0.15; P = 0.001) and among those with low carotenoids (beta = 0.16; P < 0.001) compared with babies with high levels of these micronutrients (among those with high alpha-tocopherol: beta = 0.05; P = 0.165; among those with high carotenoids: beta = 0.06; P = 0.111). These results suggest a protective effect of micronutrients on the DNA damage and potential cancer risk associated with prenatal PAH exposure.
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