Evidence map›Paper›PMID 19660859›Full record

ArticleCancer letters2010

Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.

Jennifer E Foreman, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Jeffrey M Peters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  7. Profiling of mRNA and long non-coding RNA of urothelial cancer in recipients after renal transplantation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jennifer E ForemanDepartment of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, United States.
Arun K Sharma
Shantu Amin
Frank J Gonzalez
Jeffrey M Peters
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · USNational Cancer Institute · US

Funding

Xenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4M
Modulation of skin cancer by PPARBeta/deltaR01CA124533 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PETERS, JEFFREY M · 2007 to 2017
$2.4M
Role of PPARbeta in colon carcinogenesisR01CA097999 · NCI · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETERS, JEFFREY M · 2003 to 2007
$1.4M
NCI NIH HHS CA124533NCI NIH HHS R01 CA097999NCI NIH HHS R01 CA124533
6 · The paper itself

Abstract

The effects of ligand activation of PPARbeta/delta were examined in the mouse mammary tumor cell line (C20). Expression of PPARbeta/delta was markedly lower in C20 cells as compared to the human non-tumorigenic mammary gland derived cell line (MCF10A) and mouse keratinocytes. Ligand activation of PPARbeta/delta in C20 cells caused upregulation of the PPARbeta/delta target gene angiopoietin-like 4 (Angptl4). Inhibition of C20 cell proliferation and clonogenicity was observed following treatment with GW0742 or GW501516, two highly specific PPARbeta/delta ligands. In addition, an increase in apoptosis was observed in C20 cells cultured with 10microM GW501516 that preceded the observed inhibition of cell proliferation. Results from this study show that proliferation of the C20 mouse mammary gland cancer cell line is inhibited by ligand activation of PPARbeta/delta due in part to increased apoptosis.

Indexed as

Angiopoietin-Like Protein 4AngiopoietinsAnimalsApoptosisCell Line, TumorCell ProliferationCyclooxygenase 2Dose-Response Relationship, DrugFemaleHumansLigandsMammary Neoplasms, AnimalMammary Tumor Virus, MouseMiceMice, TransgenicPhenols(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acidAngiopoietin-Like Protein 4AngiopoietinsAngptl4 protein, mouseCyclooxygenase 2GW 501516LigandsPhenolsPPAR-betaPPAR deltaSulfhydryl CompoundsThiazoles

Identifiers

PMID19660859
PMCPMC2815252
OpenAlexW2165990252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.