ArticleJournal of the American College of Cardiology2009
Mitral cerclage annuloplasty, a novel transcatheter treatment for secondary mitral valve regurgitation: initial results in swine.
Article in Journal of the American College of Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Study on Safety and Feasibility of Mitral Loop Cerclage(MLC) Annuloplasty Procedure With Investigational Medical Device (MLC-B-45-75-R and Other 11 Models) : Single-centre, Open Label, Single Arm, Feasibility Test
The Study for Atrial Functional Mitral Regurgitation Response In Mitral Loop Cerclage Annuloplasty (AFRICA Study): Multi-center, Open Label, Single Arm, Feasibility Test
Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Cerclage parahisian septal pacing through the septal perforator branch of the great cardiac vein: Bedside-to-bench development of a novel technique and lead.Heart rhythm · 2019Trial
- Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation: First Human Results.JACC. Cardiovascular interventions · 2017Trial
- EDEN (Electrocardiographic Radial Depth Navigation): A Novel Approach to Navigate Inside Heart Muscle.JACC. Clinical electrophysiology · 2023Article
- Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine.JACC. Basic to translational science · 2023Article
- Transcatheter Mitral Cerclage Ventriculoplasty: From Bench to Bedside.JACC. Cardiovascular interventions · 2022Article
- The unfinished saga of invasive procedures for secondary mitral regurgitation.Annals of cardiothoracic surgery · 2021Review
- Septal Reduction Using Transvenous Intramyocardial Cerclage Radiofrequency Ablation: Preclinical Feasibility.JACC. Basic to translational science · 2020Article
- Percutaneous Interventions for Secondary Mitral Regurgitation.Circulation. Cardiovascular interventions · 2020Review
- Two-dimensional speckle tracking echocardiography in goats: repeatability, variability, and validation of the technique using an exercise test and an experimentally induced acute ischemic cardiomyopathy.BMC veterinary research · 2020Article
- Indirect Annuloplasty to Treat Functional Mitral Regurgitation: Current Results and Future Perspectives.Frontiers in cardiovascular medicine · 2019Review
- Computational analysis of the electromechanical performance of mitral valve cerclage annuloplasty using a patient-specific ventricular model.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019Article
- Transcatheter Mitral Valve Therapy: Defining the Patient Who Will Benefit.Current cardiology reports · 2018Review
- Effects of Cinching Force on the Tricuspid Annulus: A Species Comparison.Journal of cardiovascular diseases & diagnosis · 2017Article
- Peri-procedural imaging for transcatheter mitral valve replacement.Cardiovascular diagnosis and therapy · 2016Review
- Transatrial intrapericardial tricuspid annuloplasty.JACC. Cardiovascular interventions · 2015Article
- Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation.The Annals of thoracic surgery · 2014Article
- Tension to passively cinch the mitral annulus through coronary sinus access: an ex vivo study in ovine model.Journal of biomechanics · 2014Article
- Devices for mitral valve repair.Journal of cardiovascular translational research · 2014Review
- Mitral transcatheter technologies.Rambam Maimonides medical journal · 2013Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 3 countries.
Funding
Abstract
objectivesWe developed and tested a novel transcatheter circumferential annuloplasty technique to reduce mitral regurgitation in porcine ischemic cardiomyopathy.
backgroundCatheter-based annuloplasty for secondary mitral regurgitation exploits the proximity of the coronary sinus to the mitral annulus, but is limited by anatomic variants and coronary artery entrapment.
methodsThe procedure, "cerclage annuloplasty," is guided by magnetic resonance imaging (MRI) roadmaps fused with live X-ray. A coronary sinus guidewire traverses a short segment of the basal septal myocardium to re-enter the right heart where it is exchanged for a suture. Tension is applied interactively during imaging and secured with a locking device.
resultsWe found 2 feasible suture pathways from the great cardiac vein across the interventricular septum to create cerclage. Right ventricular septal re-entry required shorter fluoroscopy times than right atrial re-entry, which entailed a longer intramyocardial traversal but did not cross the tricuspid valve. Graded tension progressively reduced septal-lateral annular diameter, but not end-systolic elastance or regional myocardial function. A simple arch-like device protected entrapped coronary arteries from compression even during supratherapeutic tension. Cerclage reduced mitral regurgitation fraction (from 22.8 +/- 12.7% to 7.2 +/- 4.4%, p = 0.04) by slice tracking velocity-encoded MRI. Flexible cerclage reduced annular size but preserved annular motion. Cerclage also displaced the posterior annulus toward the papillary muscles. Cerclage introduced reciprocal constraint to the left ventricular outflow tract and mitral annulus that enhanced leaflet coaptation. A sample of human coronary venograms and computed tomography angiograms suggested that most have suitable venous anatomy for cerclage.
conclusionsTranscatheter mitral cerclage annuloplasty acutely reduces mitral regurgitation in porcine ischemic cardiomyopathy. Entrapped coronary arteries can be protected. MRI provided insight into the mechanism of cerclage action.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.