Evidence map›Paper›PMID 19660645›Full record

ReviewProgress in brain research2009

Cell transplantation strategies for retinal repair.

E L West, R A Pearson, R E MacLaren, J C Sowden, R R Ali

Abstract readReview
In one paragraph

Review in Progress in brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 110 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. RIPK necrotic cell death pathway in both donor photoreceptor and host immune cells synergize to affect photoreceptor graft survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Article
  7. Tissue Engineering Strategies for Retina Regeneration.Applied sciences (Basel, Switzerland) · 2021
    Article
  8. Functional 3-Dimensional Retinal Organoids:Frontiers in neuroscience · 2021
    Review
  9. Article
  10. Development of Stem Cell Therapies for Retinal Degeneration.Cold Spring Harbor perspectives in biology · 2020
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  16. Immunocytochemical Profiling of Cultured Mouse Primary Retinal Cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017
    Article
  17. Article
  18. Article
  19. Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2016
    Review
  20. Photoreceptor Transplantation in Late Stage Retinal Degeneration.Investigative ophthalmology & visual science · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

E L WestDepartment of Genetics, UCL Institute of Ophthalmology, London, UK.
R A Pearson
R E MacLaren
J C Sowden
R R Ali
University College London · GBMoorfields Eye Hospital · GB

Funding

Medical Research Council G03000341Medical Research Council G0300341Medical Research Council G0601588Medical Research Council G0700438Wellcome Trust 082217
6 · The paper itself

Abstract

Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.

Indexed as

AnimalsHumansMicePhotoreceptor CellsRetinaRetinal DiseasesStem Cell Transplantation

Identifiers

PMID19660645
PMCPMC3272389
OpenAlexW1595721390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.