Trial reportPharmacology, biochemistry, and behavior2009
The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers.
Trial report in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Risk-taking and alcohol use disorders symptomatology in a sample of problem drinkers.Experimental and clinical psychopharmacology · 2011Trial
- Oxycodone lengthens reproductions of suprasecond time intervals in human research volunteers.Behavioural pharmacology · 2011Trial
- The enduring legacy of Peter B. Dews: Rate-dependency and impulsive choice.The Journal of pharmacology and experimental therapeutics · 2025Review
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Mu Opioid Receptor-Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors.Biological psychiatry · 2023Article
- Behavioral mechanisms of oxycodone's effects in female and male rats: Reinforcement delay and impulsive choice.Experimental and clinical psychopharmacology · 2023Article
- Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments.Pharmacological reviews · 2023Review
- Observational
- Pharmacological Modulation of Temporal Discounting: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Rejecting impulsivity as a psychological construct: A theoretical, empirical, and sociocultural argument.Psychological review · 2021Article
- The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies.Current addiction reports · 2021Review
- Effects of opioid/cannabinoid mixtures on impulsivity and memory in rhesus monkeys.Behavioural pharmacology · 2020Article
- Effects of oxycodone on sensitivity to reinforcement magnitude: implications for effects of opioids on impulsive and risky choice.Behavioural pharmacology · 2020Article
- The role of the opioid system in decision making and cognitive control: A review.Cognitive, affective & behavioral neuroscience · 2019Review
- Effects of morphine/CP55940 mixtures on an impulsive choice task in rhesus monkeys.Behavioural pharmacology · 2018Article
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
- Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys.Behavioural pharmacology · 2015Article
- The effect of acute morphine on delay discounting in dependent and non-dependent rats.Psychopharmacology · 2015Article
- Recent Translational Findings on Impulsivity in Relation to Drug Abuse.Current addiction reports · 2014Article
- Unidirectional relationship between heroin self-administration and impulsive decision-making in rats.Psychopharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study examined the effects of oral oxycodone, a prescription opioid, on several measures of impulsive behavior in healthy volunteers. Volunteers (n=12) participated in a four-session, double-blind, randomized design in which they received capsules containing oxycodone (5, 10, and 20 mg) or placebo. From 70 min to approximately 120 min after ingesting the capsules, subjects completed five impulsivity tasks: delay and probability discounting task, balloon analogue risk task (BART), go/no-go task, stop task, and simple reaction time test. Mood questionnaires were also completed at fixed time points in the sessions. Oxycodone produced prototypic changes in mood in a dose-related manner, but did not affect performance on any of the impulsivity tasks. Lack of effect on impulsivity stands in contrast to other studies in which other psychoactive drugs including ethanol, delta-9-tetrahydrocannabinol, and amphetamine altered behavior on one or more behavioral measures of impulsivity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.