ArticleGastroenterology2010
Phenotypic variation of colonic motor functions in chronic constipation.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
- Effects of Alfuzosin, an αClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Trial
- Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial.Digestive diseases and sciences · 2016Trial
- Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders.Neurogastroenterology and motility · 2015Trial
- Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation.Neurogastroenterology and motility · 2010Trial
- Laparoscopic total colectomy, ileal J-pouch, and ileorectal anastomosis in the treatment of slow transit constipation: a case report (with video).International journal of surgery case reports · 2026Article
- Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery.Frontiers in pharmacology · 2026Review
- 2025 Seoul Consensus on Clinical Practice Guidelines for Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2025Review
- Review
- Laparoscopic total colectomy with ileorectal anastomosis and subtotal colectomy with antiperistaltic cecorectal anastomosis for slow transit constipation.Updates in surgery · 2023Article
- Article
- Constipation and Fecal Incontinence in the Elderly.Current gastroenterology reports · 2020Review
- Mechanisms, Evaluation, and Management of Chronic Constipation.Gastroenterology · 2020Review
- Chronic Constipation.Mayo Clinic proceedings · 2019Review
- Normal colonic transit time predicts the outcome of colonic manometry in patients with chronic constipation-an exploratory study.International journal of colorectal disease · 2019Article
- Use of Bioelectronics in the Gastrointestinal Tract.Cold Spring Harbor perspectives in medicine · 2019Review
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Obstructed defecation-an enteric neuropathy? An exploratory study of patient samples.International journal of colorectal disease · 2019Article
- Editorial: Identifying Colonic Motor Dysfunction in Chronic Constipation with High-Resolution Manometry: Pan-Colonic Pressurizations.The American journal of gastroenterology · 2017Article
- High-resolution Anorectal Manometry for Identifying Defecatory Disorders and Rectal Structural Abnormalities in Women.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- Intraluminal pressure patterns in the human colon assessed by high-resolution manometry.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsColonic motor disturbances in chronic constipation (CC) are heterogeneous and incompletely understood; the relationship between colonic transit and motor activity is unclear. We sought to characterize the phenotypic variability in chronic constipation.
methodsFasting and postprandial colonic tone and phasic activity and pressure-volume relationships were assessed by a barostat manometric assembly in 35 healthy women and 111 women with CC who had normal colon transit (NTC; n = 25), slow transit (STC; n = 19), and defecatory disorders with normal (DD-normal; n = 34) or slow transit (DD-slow; n = 33). Logistic regression models assessed whether motor parameters could discriminate among these groups. Among CC, phenotypes were characterized by principal components analysis of these measurements.
resultsCompared with 10th percentile values in healthy subjects, fasting and/or postprandial colonic tone and/or compliance were reduced in 40% with NTC, 47% with STC, 53% with DD-normal, and 42% with DD-slow transit. Compared with healthy subjects, compliance was reduced (P <or= .05) in isolated STC and DD but not in NTC. Four principal components accounted for 85% of the total variation among patients: factors 1 and 2 were predominantly weighted by fasting and postprandial colonic phasic activity and tone, respectively; factor 3 by postprandial high-amplitude propagated contractions; and factor 4 by postprandial tonic response.
conclusionsFasting and/or postprandial colonic tone are reduced, reflecting motor dysfunctions, even in NTC. Colonic motor assessments allow chronic constipation to be characterized into phenotypes. Further studies are needed to evaluate the relationship among these phenotypes, enteric neuropathology, and response to treatment in CC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.