ArticleDevelopmental biology2009
Six2 activity is required for the formation of the mammalian pyloric sphincter.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Sine oculis homeobox homolog family function in gastrointestinal cancer: Progression and comprehensive analysis.World journal of clinical oncology · 2025Review
- Pseudogenization of NK3 homeobox 2 (Open biology · 2024Article
- SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells.Genes & development · 2021Article
- The Skull's Girder: A Brief Review of the Cranial Base.Journal of developmental biology · 2021Review
- Genome-wide association studies of structural birth defects: A review and commentary.Birth defects research · 2019Review
- Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett's Stemming from SPEM.Digestive diseases and sciences · 2018Review
- Translating Developmental Principles to Generate Human Gastric Organoids.Cellular and molecular gastroenterology and hepatology · 2018Review
- SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans.Journal of human genetics · 2016Article
- Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis.Cellular and molecular gastroenterology and hepatology · 2016Article
- Stomach development, stem cells and disease.Development (Cambridge, England) · 2016Review
- Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.Developmental biology · 2015Article
- Assessment of promoter methylation and expression of SIX2 as a diagnostic and prognostic biomarker in Wilms' tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.BMC biology · 2014Article
- Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.Gastroenterology · 2014Article
- Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.Nature genetics · 2012Article
- Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function.PloS one · 2012Article
- Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The functional activity of Six2, a member of the so/Six family of homeodomain-containing transcription factors, is required during mammalian kidney organogenesis. We have now determined that Six2 activity is also necessary for the formation of the pyloric sphincter, the functional gate at the stomach-duodenum junction that inhibits duodenogastric reflux. Our data reveal that several genes known to be important for pyloric sphincter formation in the chick (e.g., Bmp4, Bmpr1b, Nkx2.5, Sox9, and Gremlin) also appear to be required for the formation of this structure in mammals. Thus, we propose that Six2 activity regulates this gene network during the genesis of the pyloric sphincter in the mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.