ArticleCell regulation1990
Regulation of slug size by the cell adhesion molecule gp80 in Dictyostelium discoideum.
Article in Cell regulation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase.Cell proliferation · 2015Article
- Sociogenomics of self vs. non-self cooperation during development of Dictyostelium discoideum.BMC genomics · 2014Article
- Regulation of multiple tip formation by caffeine in cellular slime molds.BMC developmental biology · 2012Article
- Regulation of aggregate size and pattern by adenosine and caffeine in cellular slime molds.BMC developmental biology · 2012Article
- Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells.BMC developmental biology · 2012Article
- A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium.Eukaryotic cell · 2007Article
- CF45-1, a secreted protein which participates in Dictyostelium group size regulation.Eukaryotic cell · 2003Article
- The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.Molecular biology of the cell · 2000Article
- Genetic networks that regulate development in Dictyostelium cells.Microbiological reviews · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously provided in vitro evidence that the cell surface glycoprotein of Mr80,000 (gp80) of Dictyostelium discoideum is capable of mediating EDTA-resistant cell-cell binding. Expression of gp80 is specific for the aggregation stage when cells form tight aggregates. To investigate the physiological role of gp80, Dictyostelium cells were transformed with a vector containing gp80 cDNA fused to an actin promoter. gp80 transcripts were detected in transformed cells in their vegetative growth phase. Transformants at this stage also exhibited EDTA-resistant cell cohesion, thus providing direct in vivo evidence that gp80 mediates cell-cell binding via homophilic interaction. While aggregates of the parental strain KAX3 had the tendency to break up to form small slugs, transformants expressing an increased amount of gp80 were able to maintain the integrity of aggregates, giving rise to larger slugs, resulting in the formation of bigger fruiting bodies. To further demonstrate that the increase in slug size could be correlated with the expression of gp80, cells of the parental strain were treated with exogenous cAMP pulses to stimulate an over-expression of gp80. The treated cells also gave rise to larger slugs, consistent with the notion that slug size is influenced by intercellular adhesiveness during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.