ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
A serum amyloid P-binding hydrogel speeds healing of partial thickness wounds in pigs.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Multifunctional Agarose-Based Biomaterials: From Tissue Engineering and Immunomodulation to Advanced Diagnostics and Translational Applications.Gels (Basel, Switzerland) · 2026Review
- 3D-printed barbed microneedle electrodes for biosensing and drug delivery in wound management.Microsystems & nanoengineering · 2026Article
- Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.ImmunoHorizons · 2020Article
- The Development of Serum Amyloid P as a Possible Therapeutic.Frontiers in immunology · 2018Review
- A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Serum amyloid P: a systemic regulator of the innate immune response.Journal of leukocyte biology · 2014Review
- Distinct Fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.PloS one · 2014Article
- FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.Journal of leukocyte biology · 2012Article
- Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.Neurochemical research · 2012Article
- NaCl potentiates human fibrocyte differentiation.PloS one · 2012Article
- Differentiation of circulating monocytes into fibroblast-like cells.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Cell density sensing and size determination.Development, growth & differentiation · 2011Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
During wound healing, some circulating monocytes enter the wound, differentiate into fibroblast-like cells called fibrocytes, and appear to then further differentiate into myofibroblasts, cells that play a key role in collagen deposition, cytokine release, and wound contraction. The differentiation of monocytes into fibrocytes is inhibited by the serum protein serum amyloid P (SAP). Depleting SAP at a wound site thus might speed wound healing. SAP binds to some types of agarose in the presence of Ca(2+). We found that human SAP binds to an agarose with a K(D) of 7 x 10(-8) M and a B(max) of 2.1 microg SAP/mg wet weight agarose. Mixing this agarose 1 : 5 w/v with 30 microg/mL human SAP (the average SAP concentration in normal serum) in a buffer containing 2 mM Ca(2+) reduced the free SAP concentration to approximately 0.02 microg/mL, well below the concentration that inhibits fibrocyte differentiation. Compared with a hydrogel dressing and a foam dressing, dressings containing this agarose and Ca(2+) significantly increased the speed of wound healing in partial thickness wounds in pigs. This suggests that agarose/Ca(2+) dressings may be beneficial for wound healing in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.