ArticlePhotochemistry and photobiology
A role for hydrogen peroxide in the pro-apoptotic effects of photodynamic therapy.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light.New journal of chemistry = Nouveau journal de chimie · 2026Article
- Antioxidant Enzymes in Cancer Cells: Their Role in Photodynamic Therapy Resistance and Potential as Targets for Improved Treatment Outcomes.International journal of molecular sciences · 2024Review
- Virulence ofFrontiers in immunology · 2021Article
- Oxidative Stress-Inducing Anticancer Therapies: Taking a Closer Look at Their Immunomodulating Effects.Antioxidants (Basel, Switzerland) · 2020Review
- Tissue Factor-Targeted "OFrontiers in oncology · 2020Article
- Evaluation of subcutaneous infiltration of autologous platelet-rich plasma on skin-wound healing in dogs.Bioscience reports · 2017Article
- Targeted Antioxidant, Catalase-SKL, Reduces Beta-Amyloid Toxicity in the Rat Brain.Brain pathology (Zurich, Switzerland) · 2017Article
- Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.Chemical Society reviews · 2016Review
- Effect of Atmospheric-Pressure Cold Plasma on Pathogenic Oral Biofilms and In Vitro Reconstituted Oral Epithelium.PloS one · 2016Article
- Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis.Cancer medicine · 2016Article
- Amyloid-beta neuroprotection mediated by a targeted antioxidant.Scientific reports · 2014Article
- Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA.Experimental cell research · 2013Article
- Subcellular targets for photodynamic therapy: implications for initiation of apoptosis and autophagy.Journal of the National Comprehensive Cancer Network : JNCCN · 2012Article
- A targeted enzyme approach to sensitization of tyrosine kinase inhibitor-resistant breast cancer cells.Experimental cell research · 2012Article
- Light-Activated Pharmaceuticals: Mechanisms and Detection.Israel journal of chemistry · 2012Article
- Peroxisomes, cell senescence, and rates of aging.Biochimica et biophysica acta · 2012Review
- ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage.Autophagy · 2012Article
- Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.Antioxidants & redox signaling · 2012Article
- Inhibition of endocytic processes by photodynamic therapy.Lasers in surgery and medicine · 2011Article
- Enhanced efficacy of photodynamic therapy via a sequential targeting protocol.Photochemistry and photobiologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although the first reactive oxygen species (ROS) formed during irradiation of photosensitized cells is almost invariably singlet molecular oxygen (1O2), other ROS have been implicated in the phototoxic effects of photodynamic therapy (PDT). Among these are superoxide anion radical (*O2(-)), hydrogen peroxide (H2O2) and hydroxyl radical (*OH). In this study, we investigated the role of H2O2 in the pro-apoptotic response to PDT in murine leukemia P388 cells. A primary route for detoxification of cellular H2O2 involves the peroxisomal enzyme catalase. Inhibition of catalase activity by 3-amino-1,2,4-triazole led to an increased apoptotic response. PDT-induced apoptosis was impaired by addition of an exogenous recombinant catalase analog (CAT-skl) that was specifically designed to enter cells and more efficiently localize in peroxisomes. A similar effect was observed upon addition of 2,2'-bipyridine, a reagent that can chelate Fe+2, a co-factor in the Fenton reaction that results in the conversion of H2O2 to *OH. These results provide evidence that formation of H2O2 during irradiation of photosensitized cells contributes to PDT efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.