ArticleJournal of neurotrauma2009
Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity.
Article in Journal of neurotrauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Sustained delivery of chABC improves functional recovery after a spine injury.BMC neuroscience · 2022Pooled it
- Chondroitinase ABC in spinal cord injury: advances in delivery strategies and therapeutic synergies.Frontiers in bioengineering and biotechnology · 2025Review
- The Efficacy of Body-Weight Supported Treadmill Training and Neurotrophin-Releasing Scaffold in Minimizing Bone Loss Following Spinal Cord Injury.Bioengineering (Basel, Switzerland) · 2024Article
- AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Chemistry and Function of Glycosaminoglycans in the Nervous System.Advances in neurobiology · 2023Review
- Chronic muscle recordings reveal recovery of forelimb function in spinal injured female rats after cortical epidural stimulation combined with rehabilitation and chondroitinase ABC.Journal of neuroscience research · 2022Article
- Small Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration.ACS chemical neuroscience · 2022Article
- Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection.Frontiers in integrative neuroscience · 2022Article
- Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022Article
- The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord.Frontiers in cellular neuroscience · 2022Review
- Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC.ACS omega · 2021Article
- More attention on glial cells to have better recovery after spinal cord injury.Biochemistry and biophysics reports · 2021Review
- Combined treatment with enteric neural stem cells and chondroitinase ABC reduces spinal cord lesion pathology.Stem cell research & therapy · 2021Article
- Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury.Nature communications · 2020Article
- Pericytes Act as Key Players in Spinal Cord Injury.The American journal of pathology · 2019Review
- Rapid and robust restoration of breathing long after spinal cord injury.Nature communications · 2018Article
- Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.Brain : a journal of neurology · 2018Article
- The Biology of Regeneration Failure and Success After Spinal Cord Injury.Physiological reviews · 2018Review
- Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.Biomedical materials (Bristol, England) · 2018Article
- CSPGs inhibit axon branching by impairing mitochondria-dependent regulation of actin dynamics and axonal translation.Developmental neurobiology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Growth-inhibitory chondroitin sulfate proteoglycans (CSPG) are a primary target for therapeutic strategies after spinal cord injury because of their contribution to the inhibitory nature of glial scar tissue, a major barrier to successful axonal regeneration. Chondroitinase ABC (ChABC) digestion of CSPGs promotes axonal regeneration beyond a lesion site with subsequent functional improvement. ChABC also has been shown to promote sprouting of spared fibers but it is not clear if functional recovery results from such plasticity. Here we sought to better understand the roles rostral or caudal sprouting may play in ChABC-mediated functional improvement. To achieve this, ChABC or vehicle was injected rostral or caudal to a unilateral C5 injury. When injected rostral to a hemisection, ChABC promoted significant sprouting of 5HT+ fibers into dorsal and ventral horns. When ChABC was injected into tissue caudal to a hemisection, no additional sprouting was observed. When injected caudal to a hemicontusion injury, ChABC promoted sprouting of 5HT+ fibers into the ventral horn but not the dorsal horn. None of this sprouting resulted in a change in the synaptic component synapsin, nor did it impact performance in behavioral tests assessing motor function. These data suggest that ChABC-mediated sprouting of spared fibers does not necessarily translate into functional recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.