ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2009
Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-nociceptive Synapses.eNeuro · 2026Article
- Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids inFrontiers in synaptic neuroscience · 2022Article
- The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration.International journal of molecular sciences · 2021Review
- Comparative studies of endocannabinoid modulation of pain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Is plasticity of synapses the mechanism of long-term memory storage?NPJ science of learning · 2019Review
- Non-synaptic Plasticity in Leech Touch Cells.Frontiers in physiology · 2019Article
- Endocannabinoid-mediated potentiation of nonnociceptive synapses contributes to behavioral sensitization.Journal of neurophysiology · 2018Article
- Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech.Invertebrate neuroscience : IN · 2015Article
- Intracellular recording, sensory field mapping, and culturing identified neurons in the leech, Hirudo medicinalis.Journal of visualized experiments : JoVE · 2013Article
- Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The evolution and comparative neurobiology of endocannabinoid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Seasonal variation of long-term potentiation at a central synapse in the medicinal leech.The Journal of experimental biology · 2011Article
- Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.Journal of neurophysiology · 2010Article
- Properties of cannabinoid-dependent long-term depression in the leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
- Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although long-term depression (LTD) is a well-studied form of synaptic plasticity, it is clear that multiple cellular mechanisms are involved in its induction. In the leech, LTD is observed in a polysynaptic connection between touch mechanosensory neurons (T cells) and the S interneuron following low frequency stimulation. LTD elicited by 450 s low frequency stimulation was blocked by N-methyl-D-aspartic acid (NMDA) receptor antagonists. However, LTD elicited by 900 s low frequency stimulation was insensitive to NMDA receptor antagonists and was instead dependent on cannabinoid signaling. This LTD was blocked by both a cannabinoid receptor antagonist and by inhibition of diacylglycerol lipase, which is necessary for the synthesis of the cannabinoid transmitter 2-arachidonyl glycerol (2-AG). Bath application of 2-AG or the cannabinoid receptor agonist CP55 940 also induced LTD at this synapse. These results indicate that two forms of LTD coexist at the leech T-to-S polysynaptic pathway: one that is NMDA receptor-dependent and another that is cannabinoid-dependent and that activation of either form of LTD is dependent on the level of activity in this circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.