Evidence map›Paper›PMID 19657121›Full record

Trial reportThe New England journal of medicine2009

A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures.

Rachelle Buchbinder, Richard H Osborne, Peter R Ebeling, John D Wark, Peter Mitchell, Chris Wriedt, Stephen Graves, Margaret P Staples, Bridie Murphy

3 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 489 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
489citing papers in PubMed, 25 pooled it
128.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02370628 naterminatednot on this mapstarted 2015, after this paper: background citation

Vertebroplasty In The Treatment Of Acute Fracture Trial (The VITTA Trial)

TypeinterventionalSponsorCentre hospitalier de l'Université de Montréal (CHUM)Ran2015 to 2018Enrolled2ConditionsVertebral Compression FracturesArmsPercutaneous vertebroplasty, Facet block
NCT02470338 nawithdrawnnot on this mapstarted 2015, after this paper: background citation

A Single-Blinded Randomized Controlled Trial Comparing Modified Brostrӧm Procedure With and Without Diagnostic Arthroscopy for Treatment of Lateral Ankle Instability

TypeinterventionalSponsorEdna RathRan2015 to 2018Enrolled0ConditionsLateral Ankle InstabilityArmsMBP plus arthroscopy (Group A), MBP alone (Group B)
NCT03651804 phase4withdrawnnot on this mapstarted 2019, after this paper: background citation

Radiofrequency Ablation of the Medial Branch Nerve as a Novel Treatment for Posterior Element Pain From Vertebral Compression Fractures

TypeinterventionalSponsorUniversity of California, DavisRan2019 to 2023Enrolled0ConditionsVertebral Compression Fracture, Facet Joint PainArmsRadiofrequency ablation of the medial branch nerves, Non-steroidal anti-inflammatory drugs, Bisphosphonates, Acetaminophen, Physical therapy
3 · Its place in the literature

Who cites it

489 citing papers in PubMed, 25 syntheses or guidelines pooled it, 1,407 citations in OpenAlex.

  1. Guideline
  2. Conservative treatments for non-surgically managed osteoporotic vertebral compression fractures: a network meta-analysis of long-term pain and quality of life.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
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  4. Guideline
  5. Pooled it
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  10. Kyphoplasty is associated with reduced mortality risk for osteoporotic vertebral compression fractures: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Pooled it
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  12. Early cement augmentation may be a good treatment option for pain relief for osteoporotic compression fractures: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
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  16. Clinical and radiological subsequent fractures after vertebral augmentation for treating osteoporotic vertebral compression fractures: a meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Pooled it
  17. Percutaneous cement augmentation in the treatment of osteoporotic vertebral fractures (OVFs) in the elderly: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
    Pooled it
  18. Pooled it
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  20. Percutaneous vertebroplasty versus non-operative treatment for osteoporotic vertebral compression fractures: a meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Pooled it

429 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Rachelle BuchbinderMonash Department of Clinical Epidemiology, Cabrini Hospital, and Monash University, Malvern, VIC, Australia. rachelle.buchbinder@med.monash.edu.au
Richard H Osborne
Peter R Ebeling
John D Wark
Peter Mitchell
Chris Wriedt
Stephen Graves
Margaret P Staples
Bridie Murphy
University of Melbourne · AUCabrini Hospital · AUThe Alfred Hospital · AUDeakin University · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVertebroplasty has become a common treatment for painful osteoporotic vertebral fractures, but there is limited evidence to support its use.

methodsWe performed a multicenter, randomized, double-blind, placebo-controlled trial in which participants with one or two painful osteoporotic vertebral fractures that were of less than 12 months' duration and unhealed, as confirmed by magnetic resonance imaging, were randomly assigned to undergo vertebroplasty or a sham procedure. Participants were stratified according to treatment center, sex, and duration of symptoms (< 6 weeks or > or = 6 weeks). Outcomes were assessed at 1 week and at 1, 3, and 6 months. The primary outcome was overall pain (on a scale of 0 to 10, with 10 being the maximum imaginable pain) at 3 months.

resultsA total of 78 participants were enrolled, and 71 (35 of 38 in the vertebroplasty group and 36 of 40 in the placebo group) completed the 6-month follow-up (91%). Vertebroplasty did not result in a significant advantage in any measured outcome at any time point. There were significant reductions in overall pain in both study groups at each follow-up assessment. At 3 months, the mean (+/-SD) reductions in the score for pain in the vertebroplasty and control groups were 2.6+/-2.9 and 1.9+/-3.3, respectively (adjusted between-group difference, 0.6; 95% confidence interval, -0.7 to 1.8). Similar improvements were seen in both groups with respect to pain at night and at rest, physical functioning, quality of life, and perceived improvement. Seven incident vertebral fractures (three in the vertebroplasty group and four in the placebo group) occurred during the 6-month follow-up period.

conclusionsWe found no beneficial effect of vertebroplasty as compared with a sham procedure in patients with painful osteoporotic vertebral fractures, at 1 week or at 1, 3, or 6 months after treatment. (Australian New Zealand Clinical Trials Registry number, ACTRN012605000079640.)

Indexed as

VertebroplastyActivities of Daily LivingAgedBack PainBone CementsDouble-Blind MethodFemaleHumansInjections, SpinalMaleOsteoporosisPain MeasurementPlacebo EffectPolymethacrylic AcidsQuality of LifeSpinal FracturesBone Cementspolymethacrylic acidPolymethacrylic Acids

Identifiers

PMID19657121
OpenAlexW2115574045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.