ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Requirement for protein synthesis at developing synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex.Nature neuroscience · 2026Article
- Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina.Scientific reports · 2020Article
- Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.Human molecular genetics · 2017Article
- Regulation of neuronal gene expression by local axonal translation.Current genetic medicine reports · 2016Article
- The differential role of cortical protein synthesis in taste memory formation and persistence.NPJ science of learning · 2016Article
- On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors.Biomolecules · 2015Review
- Structural Components of Synaptic Plasticity and Memory Consolidation.Cold Spring Harbor perspectives in biology · 2015Review
- The translation of translational control by FMRP: therapeutic targets for FXS.Nature neuroscience · 2013Review
- Axonal translation of β-catenin regulates synaptic vesicle dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation.Frontiers in synaptic neuroscience · 2013Article
- Ca²⁺/calmodulin-dependent protein kinase II contributes to hypoxic ischemic cell death in neonatal hippocampal slice cultures.PloS one · 2013Article
- Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy.Nature neuroscience · 2012Article
- Building and remodeling synapses.Hippocampus · 2012Article
- Ultrastructure of synapses in the mammalian brain.Cold Spring Harbor perspectives in biology · 2012Review
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.Nature reviews. Neuroscience · 2012Review
- Making and breaking synapses through local mRNA regulation.Current opinion in genetics & development · 2011Review
- Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.PloS one · 2011Article
- The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.Journal of cell science · 2010Article
- Spatially restricting gene expression by local translation at synapses.Trends in neurosciences · 2010Review
Corrections and comments
- Retraction · 2013-07-03Error in Image · Unreliable Image ·
- Retracted
Authors and funding
7 authors.
Funding
Abstract
Activity and protein synthesis act cooperatively to generate persistent changes in synaptic responses. This forms the basis for enduring memory in adults. Activity also shapes neural circuits developmentally, but whether protein synthesis plays a congruent function in this process is poorly understood. Here, we show that brief periods of global or local protein synthesis inhibition decrease the synaptic vesicles available for fusion and increase synapse elimination. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a critical target; its levels are controlled by rapid turnover, and blocking its activity or knocking it down recapitulates the effects of protein synthesis inhibition. Mature presynaptic terminals show decreased sensitivity to protein synthesis inhibition, and resistance coincides with a developmental switch in regulation from CaMKII to PKA (protein kinase A). These findings demonstrate a novel mechanism regulating presynaptic activity and synapse elimination during development, and suggest that protein translation acts coordinately with activity to selectively stabilize appropriate synaptic interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.