ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed, 113 citations in OpenAlex.
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- Nanoscale Phosphoinositide Distribution on Cell Membranes of Mouse Cerebellar Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.iScience · 2023Article
- The Role of Voltage-Gated Calcium Channels in Basal Ganglia Neurodegenerative Disorders.Current neuropharmacology · 2023Review
- Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment.Frontiers in neurology · 2023Article
- Effects of progesterone on T-type-CaNeural regeneration research · 2022Article
- A Breakdown of Immune Tolerance in the Cerebellum.Brain sciences · 2022Review
- Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive NetworkFrontiers in cellular neuroscience · 2022Article
- Update on Paraneoplastic Cerebellar Degeneration.Brain sciences · 2021Review
- The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity.British journal of pharmacology · 2021Article
- Expression Pattern of T-Type CaCells · 2021Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-type voltage-gated calcium channels are expressed in the dendrites of many neurons, although their functional interactions with postsynaptic receptors and contributions to synaptic signaling are not well understood. We combine electrophysiological and ultrafast two-photon calcium imaging to demonstrate that mGluR1 activation potentiates cerebellar Purkinje cell Ca(v)3.1 T-type currents via a G-protein- and tyrosine-phosphatase-dependent pathway. Immunohistochemical and electron microscopic investigations on wild-type and Ca(v)3.1 gene knock-out animals show that Ca(v)3.1 T-type channels are preferentially expressed in Purkinje cell dendritic spines and colocalize with mGluR1s. We further demonstrate that parallel fiber stimulation induces fast subthreshold calcium signaling in dendritic spines and that the synaptic Ca(v)3.1-mediated calcium transients are potentiated by mGluR1 selectively during bursts of excitatory parallel fiber inputs. Our data identify a new fast calcium signaling pathway in Purkinje cell dendritic spines triggered by short burst of parallel fiber inputs and mediated by T-type calcium channels and mGluR1s.
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