Evidence map›Paper›PMID 19656976›Full record

ArticleJournal of clinical microbiology2009

Trichosporon mycotoxinivorans, a novel respiratory pathogen in patients with cystic fibrosis.

Patrick W Hickey, Deanna A Sutton, Annette W Fothergill, Michael G Rinaldi, Brian L Wickes, Howard J Schmidt, Thomas J Walsh

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Review
  4. Draft genome sequence ofMicrobiology resource announcements · 2026
    Article
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  6. Native Valve Endocarditis Due toJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Article
  9. The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  10. Review
  11. Antibiotics (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Bronchial Artery-Pulmonary Artery Shunt byInfection and drug resistance · 2022
    Article
  14. Complete Genome Sequencing and Comparative Analysis of the Clinically-DerivedFrontiers in cellular and infection microbiology · 2022
    Article
  15. Review
  16. Article
  17. Infection and drug resistance · 2018
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Patrick W HickeyDivision of Pediatric Infectious Disease, Walter Reed Army Medical Center, Washington, DC, USA. phickey@usuhs.mil
Deanna A Sutton
Annette W Fothergill
Michael G Rinaldi
Brian L Wickes
Howard J Schmidt
Thomas J Walsh
The University of Texas Health Science Center at San Antonio · USNational Cancer Institute · USUniformed Services University of the Health Sciences · USVirginia Commonwealth University · US

Funding

Treatment of Infections in Immunocompromised Children with Cancer, HematopoieticZ01SC006830 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI WALSH, THOMAS J. · 1996 to 2008
$5.8M
Treatment of Infections in Immunocompromised ChildrenZIASC006830 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WALSH, THOMAS J. · 2009 to 2009
$2.4M
Intramural NIH HHS
6 · The paper itself

Abstract

This report describes the molecular epidemiology, in vitro susceptibility, colonial and microscopic morphologies, and biochemical features of Trichosporon mycotoxinivorans, a newly recognized pathogen that appears to have a propensity for patients with cystic fibrosis. The index patient died with histologically documented Trichosporon pneumonia complicating cystic fibrosis. This is also the first report of disease caused by a Trichosporon species in a nontransplant patient with cystic fibrosis. As T. mycotoxinivorans has not previously been recognized as a respiratory pathogen, the significance of its recovery from sputum samples was not initially appreciated. Genetic analysis of archived clinical samples found three additional cases of T. mycotoxinivorans infection which had previously been identified as other members of the genus. An additional isolate of T. mycotoxinivorans was identified from a clinical sample on initial testing. Three of these four cases were also patients with cystic fibrosis. All isolates had MICs at 48 h of amphotericin B of > or = 1 microg/ml and of echinocandins of > or = 16 microg/ml, but they displayed various susceptibilities to the triazoles. In summary, Trichosporon mycotoxinivorans is a newly recognized human pathogen that is associated with cystic fibrosis.

Indexed as

Amphotericin BAntifungal AgentsCystic FibrosisEchinocandinsFatal OutcomeHumansLungLung Diseases, FungalMicrobial Sensitivity TestsMolecular EpidemiologyMolecular Sequence DataMycosesRadiography, ThoracicRetrospective StudiesTriazolesTrichosporonAmphotericin BAntifungal AgentsEchinocandinsTriazoles

Identifiers

PMID19656976
PMCPMC2756937
OpenAlexW2139012092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.