ArticleJournal of virology2009
Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Review
- Mouse Models for Human Herpesviruses.Pathogens (Basel, Switzerland) · 2023Review
- Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse.Retrovirology · 2021Review
- Humanized Mice for Infectious and Neurodegenerative disorders.Retrovirology · 2021Review
- Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis.Immunology · 2017Article
- Humanized Mouse Models of Clinical Disease.Annual review of pathology · 2017Review
- Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice.BMC immunology · 2016Article
- Prophylactic and therapeutic modulation of innate and adaptive immunity against mucosal infection of herpes simplex virus.Immune network · 2014Review
- NK cells in mucosal defense against infection.BioMed research international · 2014Review
- Human immune responses and potential for vaccine assessment in humanized mice.Current opinion in immunology · 2013Review
- Protective effects of red ginseng extract against vaginal herpes simplex virus infection.Journal of ginseng research · 2013Article
- Humanized mouse models of epstein-barr virus infection and associated diseases.Pathogens (Basel, Switzerland) · 2013Review
- Rapid host immune response and viral dynamics in herpes simplex virus-2 infection.Nature medicine · 2013Article
- New generation humanized mice for virus research: comparative aspects and future prospects.Virology · 2013Review
- Human hemato-lymphoid system mice: current use and future potential for medicine.Annual review of immunology · 2013Review
- Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.British journal of cancer · 2012Article
- Isolation of lymphocytes from mouse genital tract mucosa.Journal of visualized experiments : JoVE · 2012Article
- Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice.Science translational medicine · 2012Article
- What we are learning on HTLV-1 pathogenesis from animal models.Frontiers in microbiology · 2012Article
- Genital HSV-2 infection induces short-term NK cell memory.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genital herpes, caused by herpes simplex virus type 2 (HSV-2), is one of the most prevalent sexually transmitted diseases worldwide and a risk factor for acquiring human immunodeficiency virus. Although many vaccine candidates have shown promising results in animal models, they have failed to be effective in human trials. In this study, a humanized mouse strain was evaluated as a potential preclinical model for studying human immune responses to HSV-2 infection and vaccination. Immunodeficient mouse strains were examined for their abilities to develop human innate and adaptive immune cells after transplantation of human umbilical cord stem cells. A RAG2(-/-) gammac(-/-) mouse strain with a BALB/c background was chosen as the most appropriate model and was then examined for its ability to mount innate and adaptive immune responses to intravaginal HSV-2 infection and immunization. After primary infection, human cells in the lymph nodes were able to generate a protective innate immune response and produce gamma interferon (IFN-gamma). After intravaginal immunization and infection, human T cells and NK cells were found in the genital tract and iliac lymph nodes. In addition, human T cells in the spleen, lymph nodes, and vaginal tract were able to respond to stimulation with HSV-2 antigens by replicating and producing IFN-gamma. Human B cells were also able to produce HSV-2-specific immunoglobulin G. These adaptive responses were also shown to be protective and reduce local viral replication in the genital tract. This approach provides a means for studying human immune responses in vivo using a small-animal model and may become an important preclinical tool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.