ArticleJournal of virology2009
Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- The Giant Panda Transferrin Receptor Facilitates Feline Parvovirus Infection to Drive Cross-Species Transmission.Veterinary sciences · 2025Article
- Virus infection and vesicle trafficking.Frontiers in immunology · 2025Review
- The Structures and Functions of Parvovirus Capsids and Missing Pieces: the Viral DNA and Its Packaging, Asymmetrical Features, Nonprotein Components, and Receptor or Antibody Binding and Interactions.Journal of virology · 2023Review
- Nuclear entry and egress of parvoviruses.Molecular microbiology · 2022Review
- Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking.Viruses · 2022Article
- Rational Engineering and Preclinical Evaluation of Neddylation and SUMOylation Site Modified Adeno-Associated Virus Vectors in Murine Models of Hemophilia B and Leber Congenital Amaurosis.Human gene therapy · 2019Article
- Identification of a Novel Ichthyic Parvovirus in Marine Species in Hainan Island, China.Frontiers in microbiology · 2019Article
- Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range.Journal of virology · 2018Article
- Viral highway to nucleus exposed by image correlation analyses.Scientific reports · 2018Article
- Protoparvovirus Knocking at the Nuclear Door.Viruses · 2017Review
- Tctex-1 controls ciliary resorption by regulating branched actin polymerization and endocytosis.EMBO reports · 2017Article
- Host determinants of adeno-associated viral vector entry.Current opinion in virology · 2017Review
- Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages.Journal of virology · 2017Article
- Cellular transduction mechanisms of adeno-associated viral vectors.Current opinion in virology · 2016Review
- ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments.Journal of virology · 2016Article
- Structural correlates of rotavirus cell entry.PLoS pathogens · 2014Article
- Parvovirus particles and movement in the cellular cytoplasm and effects of the cytoskeleton.Virology · 2014Article
- Echovirus 7 entry into polarized caco-2 intestinal epithelial cells involves core components of the autophagy machinery.Journal of virology · 2014Article
- Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Canine parvovirus (CPV) and feline panleukopenia virus (FPV) are closely related parvoviruses that differ in their host ranges for cats and dogs. Both viruses bind their host transferrin receptor (TfR), enter cells by clathrin-mediated endocytosis, and traffic with that receptor through endosomal pathways. Infection by these viruses appears to be inefficient and slow, with low numbers of virions infecting the cell after a number of hours. Species-specific binding to TfR controls viral host range, and in this study FPV and strains of CPV differed in the levels of cell attachment, uptake, and infection in canine and feline cells. During infection, CPV particles initially bound and trafficked passively on the filopodia of canine cells while they bound to the cell body of feline cells. That binding was associated with the TfR as it was disrupted by anti-TfR antibodies. Capsids were taken up from the cell surface with different kinetics in canine and feline cells but, unlike transferrin, most did not recycle. Capsids labeled with fluorescent markers were seen in Rab5-, Rab7-, or Rab11-positive endosomal compartments within minutes of uptake, but reached the nucleus. Constitutively active or dominant negative Rab mutants changed the intracellular distribution of capsids and affected the infectivity of virus in cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.