ArticleMolecular biology of the cell2009
Udu deficiency activates DNA damage checkpoint.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Zebrafish gon4la mutants recapitulate human GON4L-related growth disorders and reveal novel metabolic organs abnormalities.Scientific reports · 2026Article
- Differential control of both cell cycle-regulated and quantitative histone mRNA expression bybioRxiv : the preprint server for biology · 2026Article
- Biallelic loss-of-function variants in GON4L cause microcephaly and brain structure abnormalities.NPJ genomic medicine · 2024Article
- The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.Experimental hematology · 2021Article
- Zebrafish Cancer Predisposition Models.Frontiers in cell and developmental biology · 2021Review
- Newly identified Gon4l/Udu-interacting proteins implicate novel functions.Scientific reports · 2020Article
- Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development.Developmental biology · 2020Article
- Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes.Nature communications · 2018Article
- The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.Frontiers in cell and developmental biology · 2018Article
- Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.Cancer research · 2016Article
- A frameshift mutation in GON4L is associated with proportionate dwarfism in Fleckvieh cattle.Genetics, selection, evolution : GSE · 2016Article
- The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.The Journal of biological chemistry · 2011Article
- The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.The Journal of experimental medicine · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Udu has been shown to play an essential role during blood cell development; however, its roles in other cellular processes remain largely unexplored. In addition, ugly duckling (udu) mutants exhibited somite and myotome boundary defects. Our fluorescence-activated cell sorting analysis also showed that the loss of udu function resulted in defective cell cycle progression and comet assay indicated the presence of increased DNA damage in udu(tu24) mutants. We further showed that the extensive p53-dependent apoptosis in udu(tu24) mutants is a consequence of activation in the Atm-Chk2 pathway. Udu seems not to be required for DNA repair, because both wild-type and udu embryos similarly respond to and recover from UV treatment. Yeast two-hybrid and coimmunoprecipitation data demonstrated that PAH-L repeats and SANT-L domain of Udu interacts with MCM3 and MCM4. Furthermore, Udu is colocalized with 5-bromo-2'-deoxyuridine and heterochromatin during DNA replication, suggesting a role in maintaining genome integrity.
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