ReviewPsychoneuroendocrinology2009
Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions.
Review in Psychoneuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 87 citations in OpenAlex.
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Effects of perinatal nutrition supplementation and early weaning on serum biochemistry, metabolomics, and reproduction in yaks.Frontiers in veterinary science · 2024Article
- Endorphins, Sexuality, and Reproduction.Advances in neurobiology · 2024Article
- Article
- Research Trends and Hot Spots of Allopregnanolone Research in the Last 20 Years: A Bibliometric Analysis.Drug design, development and therapy · 2023Review
- Beyond sex and aggression: testosterone rapidly matches behavioural responses to social context and tries to predict the future.Proceedings. Biological sciences · 2022Article
- Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus.Hormones and behavior · 2022Article
- The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins.Neurobiology of stress · 2020Article
- Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of Progestin Receptors but Relate to Increases in GABAFrontiers in endocrinology · 2020Article
- Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Astrocytes, emerging stars of energy homeostasis.Cell stress · 2018Article
- TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being.International journal of molecular sciences · 2016Article
- Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.Neural plasticity · 2016Review
- Dose-dependent effects of the antiprogestin, RU486, on sexual behavior of naturally cycling Fischer rats.Behavioural brain research · 2015Article
- Allopregnanolone as a mediator of affective switching in reproductive mood disorders.Psychopharmacology · 2014Review
- Cerebrospinal fluid cortisol and progesterone profiles and outcomes prognostication after severe traumatic brain injury.Journal of neurotrauma · 2014Article
- Article
- The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats.Frontiers in systems neuroscience · 2014Article
- The impact of sex hormone concentrations on decision-making in females and males.Frontiers in neuroscience · 2014Article
- Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hormones are trophic factors that integrate central and peripheral nervous system functions, and can influence social, cognitive, emotional and physical (SCEP) processes. Greater understanding of behavioral and neurobiological underpinnings of mental, cognitive, and/or physical changes with maturation is becoming increasingly important as the world's population ages. There are individual differences in how people age, but the factors that influence these differences are not well understood. Social supports are one factor that may influence the trajectory of age-related processes. The loss of close relationships, especially among older persons, is one of the greatest risk factors for mental and physical decline. Progesterone, secreted by the ovaries, or produced de novo in the brain, is readily converted centrally to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), and can influence SCEP, through rapid, non-classical steroid-mediated actions. Our hypothesis is that 3alpha,5alpha-THP is a key trophic factor in SCEP and development. Our research has demonstrated that 3alpha,5alpha-THP facilitates social and sexual behavior of rodents, which evokes further increases in 3alpha,5alpha-THP in midbrain and hippocampus, brain areas involved in SCEP. The role of 3alpha,5alpha-THP to influence social and/or sexual experience, and thereby SCEP, is discussed in this review. Further understanding of these neurobiological and/or behavioral factors may lead to findings that ultimately can promote health and prevent disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.