ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2009
How do common chronic conditions affect health-related quality of life?
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 5 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Occupational Mobility and Chronic Health Conditions in Middle and Later Life: A Systematic Review.International journal of behavioral medicine · 2023Pooled it
- Health-related quality of life in adult patients with asthma according to asthma control and severity: A systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2017Pooled it
- Multimorbidity and functional decline in community-dwelling adults: a systematic review.Health and quality of life outcomes · 2015Pooled it
- Self management for patients with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2014Pooled it
- Normative data for the BODY-Q module in an Australian population and comparison with North American and European norms.JPRAS open · 2026Article
- Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study.Journal of bone and mineral metabolism · 2026Article
- Gig work dependence and psychological distress in chronic illness.SSM - population health · 2026Article
- Living well with long-term conditions: A quantitative investigation into the influences of illness and healthcare experiences.Chronic illness · 2026Article
- Analysing the impact of complex multimorbidity on health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Article
- Life after hepatorenal syndrome: unraveling quality of life, psychological distress, and treatment preferences.BMC palliative care · 2025Article
- Trajectories of Physical Disabilities Over 6 Months in Patients With Long COVID.Physical therapy · 2025Article
- Beyond illness: how chronic conditions and unhealthy behaviors impact health-related quality of life among Iranian women.BMC public health · 2025Article
- Social prescribing for people living with long-term health conditions: a scoping review.Systematic reviews · 2025Article
- Quantifying the burden of hereditary hemorrhagic telangiectasia on quality of life and psychological health: a cross-sectional study.Orphanet journal of rare diseases · 2025Article
- A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study.Open forum infectious diseases · 2025Article
- Mental health and health-related quality of life among adults with osteoarthritis: A national population-based study.PloS one · 2025Article
- Relationship between health literacy and health-related quality of life in Korean adults with chronic diseases.PloS one · 2024Article
- Article
29 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComorbidity is common. National Institute for Health and Clinical Excellence (NICE) guidelines have been created to make best use of resources to improve patients' quality of life but do not currently take account of comorbidity. The effect of multiple chronic conditions with regard to health-related quality of life (HRQoL) is poorly researched. Criticisms of previous research have been due to patient-defined chronic conditions, lack of quantification of the effects of confounding factors, selection of affected patients only, small sample sizes, and upper age limits.
aimThis study aims to address these issues, looking into the impact of combinations of chronic conditions on HRQoL. DESIGN OF THE STUDY: Participants filled in a questionnaire containing general health information, specific respiratory questions, and the EQ-5D measure of HRQoL. The questionnaires were then matched up to their GP records to obtain their disease status for six common chronic diseases (asthma, chronic obstructive pulmonary disease, ischaemic heart disease, hypertension, diabetes, and cerebrovascular disease).
methodData from a mailed questionnaire were analysed from 5169 patients aged >16 years from two general practices in Wythenshawe, Manchester in 2004. Completion of the questionnaire was taken to indicate consent to participate.
resultsSignificant correlations were found between a lower HRQoL and increasing numbers of chronic conditions (P<0.001), increasing age, possible obstructive airway disease, lack of higher education, smoking, and female sex. These all remained significant following regression, except for sex, with number of chronic conditions being a strong predictor of the weighted health state index score, EQ-5D(index) (coefficient = -0.079, P<0.001).
conclusionIncreasing numbers of chronic conditions have a strong negative effect on HRQoL.
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