ArticleBMC complementary and alternative medicine2009
Inhibition of HIV-1 entry by extracts derived from traditional Chinese medicinal herbal plants.
Article in BMC complementary and alternative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 48 citations in OpenAlex.
- Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint.Animal models and experimental medicine · 2025Review
- Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19.Journal of clinical medicine · 2020Review
- Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1.Natural products and bioprospecting · 2020Article
- The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy.International journal of genomics · 2019Review
- Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression.Retrovirology · 2018Article
- An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine.Frontiers of medicine · 2014Observational
- HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.Retrovirology · 2014Article
- HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication.PloS one · 2014Article
- Extracts of medicinal herbYao wu shi pin fen xi = Journal of food and drug analysis · 2013Article
- Melaleuca alternifolia concentrate inhibits in vitro entry of influenza virus into host cells.Molecules (Basel, Switzerland) · 2013Article
- Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity.BMC complementary and alternative medicine · 2011Article
- Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.Journal of ethnobiology and ethnomedicine · 2010Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHighly active anti-retroviral therapy (HAART) is the current HIV/AIDS treatment modality. Despite the fact that HAART is very effective in suppressing HIV-1 replication and reducing the mortality of HIV/AIDS patients, it has become increasingly clear that HAART does not offer an ultimate cure to HIV/AIDS. The high cost of the HAART regimen has impeded its delivery to over 90% of the HIV/AIDS population in the world. This reality has urgently called for the need to develop inexpensive alternative anti-HIV/AIDS therapy. This need has further manifested by recent clinical trial failures in anti-HIV-1 vaccines and microbicides. In the current study, we characterized a panel of extracts of traditional Chinese medicinal herbal plants for their activities against HIV-1 replication.
methodsCrude and fractionated extracts were prepared from various parts of nine traditional Chinese medicinal herbal plants in Hainan Island, China. These extracts were first screened for their anti-HIV activity and cytotoxicity in human CD4+ Jurkat cells. Then, a single-round pseudotyped HIV-luciferase reporter virus system (HIV-Luc) was used to identify potential anti-HIV mechanisms of these extracts.
resultsTwo extracts, one from Euphorbiaceae, Trigonostema xyphophylloides (TXE) and one from Dipterocarpaceae, Vatica astrotricha (VAD) inhibited HIV-1 replication and syncytia formation in CD4+ Jurkat cells, and had little adverse effects on host cell proliferation and survival. TXE and VAD did not show any direct inhibitory effects on the HIV-1 RT enzymatic activity. Treatment of these two extracts during the infection significantly blocked infection of the reporter virus. However, pre-treatment of the reporter virus with the extracts and treatment of the extracts post-infection had little effects on the infectivity or gene expression of the reporter virus.
conclusionThese results demonstrate that TXE and VAD inhibit HIV-1 replication likely by blocking HIV-1 interaction with target cells, i.e., the interaction between gp120 and CD4/CCR5 or gp120 and CD4/CXCR4 and point to the potential of developing these two extracts to be HIV-1 entry inhibitors.
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