Evidence map›Paper›PMID 19656375›Full record

ArticleBMC cancer2009

Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China.

Ying Gao, Nan Hu, XiaoYou Han, Carol Giffen, Ti Ding, Alisa Goldstein, Philip Taylor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  8. Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma.Esophagus : official journal of the Japan Esophageal Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ying GaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. gaoying@mail.nih.gov
Nan Hu
XiaoYou Han
Carol Giffen
Ti Ding
Alisa Goldstein
Philip Taylor
Division of Cancer Epidemiology and GeneticsShanxi Provincial Cancer Hospital · CNInformation Management Services · USNational Cancer Institute · US

Funding

Intramural NIH HHS
6 · The paper itself

Abstract

backgroundFamily history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse.

methods600 esophageal squamous cell carcinoma (ESCC) cases, 598 gastric cardia adenocarcinoma cases, and 316 gastric non-cardia adenocarcinoma cases, and 1514 age-, gender-, and neighborhood-matched controls were asked for FH in first degree relatives and non-blood relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regressions, and hazard ratios (HRs) from Cox proportional hazard regressions were estimated.

resultsIncreased ESCC risk was associated with FH of any cancer (OR = 1.72, 95% CI = 1.39-2.12), FH of any UGI cancer (OR = 2.28, 95%CI = 1.77-2.95) and FH of esophageal cancer (OR = 2.84, 95%CI = 2.09-3.86), but not FH of non-UGI cancer. Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk. FH of gastric cardia cancer was associated with an increased risk of all three cancers. Cancer in non-blood relatives was not associated with risk of any UGI cancer. FH of UGI cancer was associated with a poorer survival rate among younger ESCC cases (HR = 1.82, 95%CI = 1.01-3.29).

conclusionThese data provide strong evidence that shared susceptibility is involved in esophageal carcinogenesis and also suggest a role in prognosis.

Indexed as

AgedChinaEsophageal NeoplasmsFamily HealthFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedOdds RatioRegression AnalysisRiskStomach NeoplasmsTreatment Outcome

Identifiers

PMID19656375
PMCPMC2729777
OpenAlexW2012440275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.