ReviewDigestive diseases and sciences2009
Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics.
Review in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.Nature reviews. Gastroenterology & hepatology · 2022Review
- A Swedish national adoption study of risk of irritable bowel syndrome (IBS).BMJ open gastroenterology · 2017Article
- Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.Frontiers in psychiatry · 2015Review
- Irritable bowel syndrome: the evolution of multi-dimensional looking and multidisciplinary treatments.World journal of gastroenterology · 2014Review
- Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- IBS and the role of otilonium bromide.International journal of colorectal disease · 2013Review
- Psychosocial determinants of irritable bowel syndrome.World journal of gastroenterology · 2012Review
- Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.Journal of neurogastroenterology and motility · 2011Article
- A Klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea.Gastroenterology · 2011Article
- Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.Current opinion in pharmacology · 2011Review
- From cytokines to toll-like receptors and beyond - current knowledge and future research needs in irritable bowel syndrome.Journal of neurogastroenterology and motility · 2010Article
- Irritable bowel syndrome: a review article.Middle East journal of digestive diseases · 2010Review
- Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.Therapeutic advances in gastroenterology · 2010Article
- IBS: An epigenetic perspective.Nature reviews. Gastroenterology & hepatology · 2010Review
- Irritable bowel syndrome symptoms and health related quality of life in female veterans.Alimentary pharmacology & therapeutics · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeFamilial aggregation and sibling pair studies suggest there is a genetic contribution to the development of irritable bowel syndrome (IBS). The aim of this study was to review the evidence of genetics in IBS based on genetic epidemiology, studies of association with intermediate phenotypes and pharmacogenetics.
resultsGenetic association studies with IBS symptom phenotype have generally provided inconsistent results for many candidate genes investigated, such as SLC6A4, GNB3, and IL-10. There have been no genome-wide association studies in IBS to date. Studies of associations of candidate genes with intermediate phenotypes suggest associations with pathophysiological mechanisms of motor and sensory functions; however, these results also require replication. Pharmacogenetics studies illustrate the potential of genetics to impact on response to therapy, as observed with SLC6A4 and responses to the 5-HT3 antagonist alosetron and the 5-HT4 agonist, tegaserod.
conclusionsWhile the heritable component and genetics in the complex disorder of IBS are still poorly understood, studies of the associations of spontaneous genetic variations and altered functions may provide novel insights of the mechanisms contributing to the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.