ReviewHandbook of experimental pharmacology2009
Sensory nerves and airway irritability.
Review in Handbook of experimental pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Article
- MrgprC11American journal of respiratory cell and molecular biology · 2025Article
- Mediation Effect of CSF Substance P on the Association Between Smoking and Sleep.Brain and behavior · 2025Article
- Schwann cells in the normal and pathological lung microenvironment.Frontiers in molecular biosciences · 2024Review
- Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis.The American journal of tropical medicine and hygiene · 2023Article
- Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation.Toxicology letters · 2023Article
- Transformation of Our Understanding of Breathing Control by Molecular Tools.Annual review of physiology · 2023Review
- The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats.Annals of translational medicine · 2023Article
- A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies.Frontiers in pharmacology · 2022Review
- WAO-ARIA consensus on chronic cough - Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways.The World Allergy Organization journal · 2021Review
- Antitussive effects of NaEuropean journal of pharmacology · 2021Article
- A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction.Brain, behavior, and immunity · 2020Article
- Article
- Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons.Molecular neurobiology · 2020Article
- Effect of neuromedin U on allergic airway inflammation in an asthma model.Experimental and therapeutic medicine · 2020Review
- Sense and Immunity: Context-Dependent Neuro-Immune Interplay.Frontiers in immunology · 2017Review
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.Respiratory research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The lung, like many other organs, is innervated by a variety of sensory nerves and by nerves of the parasympathetic and sympathetic nervous systems that regulate the function of cells within the respiratory tract. Activation of sensory nerves by both mechanical and chemical stimuli elicits a number of defensive reflexes, including cough, altered breathing pattern, and altered autonomic drive, which are important for normal lung homeostasis. However, diseases that afflict the lung are associated with altered reflexes, resulting in a variety of symptoms, including increased cough, dyspnea, airways obstruction, and bronchial hyperresponsiveness. This review summarizes the current knowledge concerning the physiological role of different sensory nerve subtypes that innervate the lung, the factors which lead to their activation, and pharmacological approaches that have been used to interrogate the function of these nerves. This information may potentially facilitate the identification of novel drug targets for the treatment of respiratory disorders such as cough, asthma, and chronic obstructive pulmonary disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.