ReviewJournal of cardiovascular translational research2009
Influence of maternal dysmetabolic conditions during pregnancy on cardiovascular disease.
Review in Journal of cardiovascular translational research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Association between maternal personality traits and fetal atherogenic indices: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
- Maternal high-cholesterol diet negatively programs offspring bone development and downregulates hedgehog signaling in osteoblasts.The Journal of biological chemistry · 2022Article
- Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease.Biomedicines · 2021Review
- Maternal cholesterol levels during gestation: boon or bane for the offspring?Molecular and cellular biochemistry · 2021Review
- The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women: a systematic review and meta-analysis of randomized controlled trials.Journal of diabetes and metabolic disorders · 2020Review
- Early Pregnancy Cardiovascular Health and Subclinical Atherosclerosis.Journal of the American Heart Association · 2019Article
- High Fat Programming and Cardiovascular Disease.Medicina (Kaunas, Lithuania) · 2018Review
- Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2018Article
- Mitochondrial health, the epigenome and healthspan.Clinical science (London, England : 1979) · 2016Review
- Association of Maternal Prepregnancy Dyslipidemia With Adult Offspring Dyslipidemia in Excess of Anthropometric, Lifestyle, and Genetic Factors in the Framingham Heart Study.JAMA cardiology · 2016Article
- Increased systolic load causes adverse remodeling of fetal aortic and mitral valves.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Sex-Specific Parental Effects on Offspring Lipid Levels.Journal of the American Heart Association · 2015Article
- Lipopolysaccharide exposure during pregnancy leads to aortic dysfunction in offspring rats.PloS one · 2014Article
- Prevention of non-communicable diseases requires a life course approach: a case study from Kerala.The Indian journal of medical research · 2013Article
- Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat.Diabetologia · 2011Article
- Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.American journal of obstetrics and gynecology · 2011Article
- Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy.Experimental diabetes research · 2011Review
- Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice.PloS one · 2011Article
- Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition.Proceedings of the National Academy of Sciences of the United States of America · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Pathogenic factors associated with maternal hypercholesterolemia, obesity, and diabetic conditions during pregnancy influence fetal development and predispose offspring to cardiovascular disease. Animal models have established cause-effect relationships consistent with epidemiological findings in humans and have demonstrated, in principle, that interventions before or during pregnancy can reduce or prevent pathogenic in utero programming. However, little is known about the mechanisms by which maternal dysmetabolic conditions enhance disease susceptibility in offspring. Identification of these mechanisms is rendered more difficult by the fact that programming effects in offspring may be latent and may require conventional risk factors and inherited genetic co-factors to become clinically manifest. Given the increasing prevalence of maternal risk factors, which is expected to lead to a wave of cardiovascular disease in the coming decades, and the length of prospective studies on developmental programming in humans, greater-than-usual emphasis on experimental models and translational studies is necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.