ReviewEnvironmental health perspectives2009
Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes.
Review in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 279 citations in OpenAlex.
- Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan.Environment internationalPooled it
- Studying endocrine disrupting chemicals from molecular targets to mixture model approach: lessons from the thyroid model.The Journal of clinical endocrinology and metabolism · 2026Review
- New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS).Chemical research in toxicology · 2026Article
- Optimal testing time for cerebral heterotopia formation in the rat comparative thyroid assay, a downstream indicator for perinatal thyroid hormone insufficiency.Journal of toxicologic pathology · 2024Article
- Specific effects on the thyroid relevant for performing a dietary cumulative risk assessment of pesticide residues: 2024 update.EFSA journal. European Food Safety Authority · 2024Article
- A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka.Environmental science & technology · 2024Article
- Prenatal test cohort of a modified rat comparative thyroid assay adding brain thyroid hormone measurements and histology but lowering group size appears able to detect disruption by sodium phenobarbital.Current research in toxicology · 2024Article
- Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model.Toxicology and applied pharmacology · 2023Article
- Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.Journal of exposure science & environmental epidemiology · 2023Article
- Geophagia: Benefits and potential toxicity to human-A review.Frontiers in public health · 2022Review
- Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones.American journal of epidemiology · 2021Article
- Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio).Neurotoxicology · 2021Article
- Protective effects of selenium and zinc against potassium dichromate-induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats.Environmental science and pollution research international · 2021Article
- Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment.Environmental research · 2021Article
- Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women.Environmental research · 2021Article
- Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes.Journal of diabetes research · 2021Article
- Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats.Environmental science and pollution research international · 2020Article
- Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach.Environment international · 2020Article
- Prenatal dioxin exposure and thyroid hormone levels in the Seveso second generation study.Environmental research · 2020Article
- Critical Review of Read-Across Potential in Testing for Endocrine-Related Effects in Vertebrate Ecological Receptors.Environmental toxicology and chemistry · 2020Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health.
objectivesWe review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals. DATA SOURCES: We drew on an extensive body of epidemiologic, toxicologic, and mechanistic studies. DATA SYNTHESIS: THs are critical for normal nervous system development, and decreased maternal TH levels are associated with adverse neuropsychological development in children. In adult humans, increased thyroid-stimulating hormone is associated with increased blood pressure and poorer blood lipid profiles, both risk factors for cardiovascular disease and death. These effects of thyroid suppression are observed even within the "normal" range for the population. Environmental chemicals may affect thyroid homeostasis by a number of mechanisms, and multiple chemicals have been identified that interfere with thyroid function by each of the identified mechanisms.
conclusionsIndividuals are potentially vulnerable to adverse effects as a consequence of exposure to thyroid-disrupting chemicals. Any degree of thyroid disruption that affects TH levels on a population basis should be considered a biomarker of adverse outcomes, which may have important societal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.