ArticleOptics express2009
A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces.
Article in Optics express, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Bloch Surface Wave-Coupled Emission at Ultra-Violet Wavelengths.The journal of physical chemistry. C, Nanomaterials and interfaces · 2016Article
- Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review.IEEE sensors journal · 2016Article
- High sensitivity automated multiplexed immunoassays using photonic crystal enhanced fluorescence microfluidic system.Biosensors & bioelectronics · 2015Article
- Label-Free Biosensor Imaging on Photonic Crystal Surfaces.Sensors (Basel, Switzerland) · 2015Review
- Directing fluorescence with plasmonic and photonic structures.Accounts of chemical research · 2015Article
- Spatial Resolution and Refractive Index Contrast of Resonant Photonic Crystal Surfaces for Biosensing.IEEE photonics journal · 2015Article
- Review
- On-chip detection of a single nucleotide polymorphism without polymerase amplification.Nano research · 2014Article
- Radiative decay engineering 6: fluorescence on one-dimensional photonic crystals.Analytical biochemistry · 2013Article
- Sensitive detection of protein and miRNA cancer biomarkers using silicon-based photonic crystals and a resonance coupling laser scanning platform.Lab on a chip · 2013Article
- Article
- Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.Journal of biophotonics · 2012Review
- Multiplexed cancer biomarker detection using quartz-based photonic crystal surfaces.Analytical chemistry · 2012Article
- High-Q optical sensors for chemical and biological analysis.Analytical chemistry · 2012Review
- Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays.Optics express · 2011Article
- Photobleaching on photonic crystal enhanced fluorescence surfaces.Journal of fluorescence · 2011Article
- Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection.Optics express · 2010Article
- Photonic Crystal Surfaces as a General Purpose Platform for Label-Free and Fluorescent Assays.JALA (Charlottesville, Va.) · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We report on the design and demonstration of an optical imaging system capable of exciting surface-bound fluorophores within the resonant evanescent electric field of a photonic crystal surface and gathering fluorescence emission that is directed toward the imaging objective by the photonic crystal. The system also has the ability to quantify shifts in the local resonance angle induced by the adsorption of biomolecules on the photonic crystal surface for label-free biomolecular imaging. With these two capabilities combined within a single detection system, we demonstrate label-free images self-registered to enhanced fluorescence images with 328x more sensitive fluorescence detection relative to a glass surface. This technique is applied to a DNA microarray where label-free quantification of immobilized capture DNA enables improved quality control and subsequent enhanced fluorescence detection of dye-tagged hybridized DNA yields 3x more genes to be detected versus commercially available microarray substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.