Trial reportBehavioural pharmacology2009
Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers.
Trial report in Behavioural pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Individual differences in the reinforcing and subjective effects of d-amphetamine: Dimensions of impulsivity.Experimental and clinical psychopharmacology · 2016Trial
- The amphetamine response moderates the relationship between negative emotionality and alcohol use.Alcoholism, clinical and experimental research · 2013Trial
- Effects of 24 hours of tobacco withdrawal and subsequent tobacco smoking among low and high sensation seekers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Trial
- The reinforcing, subject-rated, performance, and cardiovascular effects of d-amphetamine: influence of sensation-seeking status.Addictive behaviors · 2007Trial
- Similarities and Differences in Psychology.Advances in experimental medicine and biology · 2025Review
- An insula-driven network computes decision uncertainty and promotes abstinence in chronic cocaine users.The European journal of neuroscience · 2020Article
- Article
- Sex matters: females in proestrus show greater diazepam anxiolysis and brain-derived neurotrophin factor- and parvalbumin-positive neurons than males.The European journal of neuroscience · 2018Article
- Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans.Frontiers in pharmacology · 2018Article
- Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models.Current neuropharmacology · 2016Review
- Novelty Seeking as a Phenotypic Marker of Adolescent Substance Use.Substance abuse : research and treatment · 2015Article
- Separate and combined effects of the GABAA positive allosteric modulator diazepam and Δ⁹-THC in humans discriminating Δ⁹-THC.Drug and alcohol dependence · 2014Article
- Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish.Brain research · 2013Article
- Individual differences and social influences on the neurobehavioral pharmacology of abused drugs.Pharmacological reviews · 2013Review
- Amphetamine self-administration in light and moderate drinkers.Alcoholism, clinical and experimental research · 2011Article
- Novelty seeking, incentive salience and acquisition of cocaine self-administration in the rat.Behavioural brain research · 2011Article
- A possible link between sensation-seeking status and positive subjective effects of oxycodone in healthy volunteers.Pharmacology, biochemistry, and behavior · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although sensation-seeking status is associated with age of initiation and amount of drug use among adolescents, and sensitivity to the behavioral and reinforcing effects of drugs among young adults, it is unclear whether sensation-seeking status among adolescents is predictive of sensitivity to the pharmacological effects of drugs (i.e. abuse potential) as adults. This study examined the acute behavioral effects of oral diazepam and d-amphetamine in young adults, ages 18-21 years, who had consistently scored in the highest or lowest third of their grade-based cohort on a modified Sensation Seeking Scale that was completed annually between ages 10 and 14 years. Healthy participants completed 16 7.5-h test days, with test days separated by a minimum of 48 h. Each day, assessments consisting of computer task performance, verbal report of drug effects, and cardiovascular measures were completed 0, 50, 110, 170, 230, and 290 min after drug administration. Placebo and three active doses of diazepam and d-amphetamine (2.5, 5.0 and 10.0 mg/70 kg) were tested under double-blind conditions according to a randomized-block design. Typical stimulant and sedative effects were obtained with d-amphetamine and diazepam, respectively. Drug effects varied as a function of sensation-seeking status, with magnitude of effects on cardiovascular function, task performance, and report of positive drug effects being greater among high sensation seekers, and report of negative drug effects being greater among low sensation seekers. Adolescents who report high levels of sensation seeking on a consistent basis are more sensitive to pharmacological effects of stimulant and sedative drugs that are associated with abuse potential as young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.