Evidence map›Paper›PMID 19654303›Full record

SynthesisCancer research2009

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

Peter Broderick, Yufei Wang, Jayaram Vijayakrishnan, Athena Matakidou, Margaret R Spitz, Timothy Eisen, Christopher I Amos, Richard S Houlston

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 32 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 32 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 32 syntheses or guidelines pooled it, 234 citations in OpenAlex.

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  14. Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Pooled it
  15. BAT3 rs1052486 and rs3117582 polymorphisms are associated with lung cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  18. Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  19. Quantitative assessment of the influence of common variations on 6p21 and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Peter BroderickInstitute of Cancer Research, Sutton, Surrey, United Kingdom.
Yufei Wang
Jayaram Vijayakrishnan
Athena Matakidou
Margaret R Spitz
Timothy Eisen
Christopher I Amos
Richard S Houlston
Institute of Cancer Research · GBThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GB

Funding

ECOGENETIC STUDY OF LUNG CANCER IN MINORITIESR01CA055769 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SPITZ, MARGARET R · 1991 to 2008
$5.3M
Inflammation Genes and Lung Cancer RiskR01CA127219 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SPITZ, MARGARET R · 2008 to 2013
$3.1M
High Density Association Analysis of Lung CancerR01CA121197 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2010
$3.0M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
Cancer Research UK C1298/A8362Cancer Research UK C1298/A8780Medical Research Council G0000934NCI NIH HHS 5R01CA055769NCI NIH HHS 5R01CA121197NCI NIH HHS 5R01CA127219NCI NIH HHS 5R01CA133996NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS R01 CA133996Wellcome Trust
6 · The paper itself

Abstract

To explore the impact of common variation on the risk of developing lung cancer, we conducted a two-phase genome-wide association (GWA) study. In phase 1, we compared the genotypes of 511,919 tagging single nucleotide polymorphisms (SNP) in 1,952 cases and 1,438 controls; in phase 2, 30,568 SNPs were genotyped in 2,465 cases and 3,005 controls. SNP selection was based on best supported P values from phase 1 and two other GWA studies of lung cancer. In the combined analysis of phases 1 and 2, the strongest associations identified were defined by SNPs mapping to 15q25.1 (rs12914385; P = 3.19 x 10(-16)), 5p15.33 (rs4975616; P = 6.66 x 10(-7)), and 6p21.33 (rs3117582; P = 9.13 x 10(-7)). Variation at 15q25.1, but not 5p15.33 or 6p21.33, was strongly associated with smoking behavior with risk alleles correlated to higher consumption. Variation at 5p15.33 was shown to significantly influence induction of lung cancer histology. Pooling data from the four series provided 21,620 genotypes for 7,560 cases and 8,205 controls. A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk. The next best-supported associations were attained at 15q15.2 (rs748404: P = 1.08 x 10(-6)) and 10q23.31 (rs1926203; P = 1.28 x 10(-6)). These data indicate few common variants account for 1% of the excess familial risk underscoring the necessity of having additional large sample series for gene discovery.

Indexed as

Genetic Predisposition to DiseaseAgedAlgorithmsCarcinoma, Non-Small-Cell LungCase-Control StudiesFemaleGenome-Wide Association StudyHumansLinkage DisequilibriumLung NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideRiskSmall Cell Lung CarcinomaUnited Kingdom

Identifiers

PMID19654303
PMCPMC2754318
OpenAlexW2075040668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.