ReviewThe Plant cell2009
Association mapping: critical considerations shift from genotyping to experimental design.
Review in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 366 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
366 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta genetic analysis of melon sweetness.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Pooled it
- Development of an open-pollinated genetic mapping framework to facilitate the identification of QTL in apples.The plant genome · 2026Article
- Genome-Wide Identification of Melon Single-Nucleotide Polymorphisms and Structural Variations Associated with Resistance toPlants (Basel, Switzerland) · 2026Article
- Identification and genomic location of resistance to bacterial leaf streak of barley.The plant genome · 2026Article
- Haplotype-based multi-locus genome-wide association study reveals genomic regions associated with reproductive stage high temperature stress tolerance in rice.Plant molecular biology · 2026Article
- Dissecting the genetic basis of relevant fruit quality traits in interspecific grapevines (Horticulture research · 2026Article
- Integrating Meta-QTL Analysis and Genome-Wide Association Mapping in Ethiopian Sesame (Plants (Basel, Switzerland) · 2026Article
- Targeted expansion of a barley genebank core collection facilitates the discovery of disease resistance loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- Article
- Multi-model genome-wide association studies identify stable QTLs and candidate genes for lodging resistance inFrontiers in plant science · 2026Article
- Mean and variance heterogeneity loci impact kernel compositional traits in maize.The plant genome · 2025Article
- Genome-wide association study of seedling leaf rust resistance in European winter wheat cultivars.Journal of applied genetics · 2025Article
- Combination of QTL mapping and GWAS for fine mapping and gene mining of drought tolerance and seed yield components in faba bean (Vicia faba L.).BMC plant biology · 2025Article
- Genetic structure and marker-trait association analysis for agro-morphological and physiological characteristics in germplasm of wild barley (Hordeum vulgare subsp. spontaneum).Scientific reports · 2025Article
- Genome-wide association mapping reveals genetic loci underlying phenotypic variation in early root vigour improvement induced by osmopriming in Brassica napus L.BMC plant biology · 2025Article
- Association Mapping Analysis of Morphological Characteristics in FPlants (Basel, Switzerland) · 2025Article
- Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.).BMC plant biology · 2025Article
- Trans-regulatory loci shape natural variation of gene expression plasticity in Arabidopsis.Genetics · 2025Article
- Morphological and Pomological Characterizations of Peach [Food science & nutrition · 2025Article
306 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of many plant scientists' research is to explain natural phenotypic variation in terms of simple changes in DNA sequence. Traditionally, linkage mapping has been the most commonly employed method to reach this goal: experimental crosses are made to generate a family with known relatedness, and attempts are made to identify cosegregation of genetic markers and phenotypes within this family. In vertebrate systems, association mapping (also known as linkage disequilibrium mapping) is increasingly being adopted as the mapping method of choice. Association mapping involves searching for genotype-phenotype correlations in unrelated individuals and often is more rapid and cost-effective than traditional linkage mapping. We emphasize here that linkage and association mapping are complementary approaches and are more similar than is often assumed. Unlike in vertebrates, where controlled crosses can be expensive or impossible (e.g., in humans), the plant scientific community can exploit the advantages of both controlled crosses and association mapping to increase statistical power and mapping resolution. While the time and money required for the collection of genotype data were critical considerations in the past, the increasing availability of inexpensive DNA sequencing and genotyping methods should prompt researchers to shift their attention to experimental design. This review provides thoughts on finding the optimal experimental mix of association mapping using unrelated individuals and controlled crosses to identify the genes underlying phenotypic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.