ArticleMethods (San Diego, Calif.)2010
Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry.
Article in Methods (San Diego, Calif.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Trial
- Alzheimer's disease-related cortical proteins modify the association of brain insulin signaling with cognitive decline.Journal of Alzheimer's disease : JAD · 2025Article
- Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage.Neurobiology of aging · 2025Article
- Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.Molecular neurodegeneration · 2024Article
- A comprehensive multi-omics analysis reveals unique signatures to predict Alzheimer's disease.Frontiers in bioinformatics · 2024Article
- Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease.Neurobiology of aging · 2023Article
- Association of small vessel disease with tau pathology.Acta neuropathologica · 2022Article
- Integrative-omics for discovery of network-level disease biomarkers: a case study in Alzheimer's disease.Briefings in bioinformatics · 2021Article
- BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.Molecular neurodegeneration · 2020Article
- Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.Nature medicine · 2020Article
- Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso.PloS one · 2020Article
- The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.Brain communications · 2020Article
- Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.Neurobiology of aging · 2019Article
- Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.JAMA neurology · 2019Article
- Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons.Journal of affective disorders · 2019Article
- Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.Nature communications · 2019Article
- Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.Annals of neurology · 2018Article
- The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia.Frontiers in neuroscience · 2018Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Changes of Protein Turnover in AgingMolecular & cellular proteomics : MCP · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
Voxelation creates expression atlases by high-throughput analysis of spatially registered cubes or voxels harvested from the brain. The modality independence of voxelation allows a variety of bioanalytical techniques to be used to map abundance. Protein expression patterns in the brain can be obtained using liquid chromatography (LC) combined with mass spectrometry (MS). Here we describe the methodology of voxelation as it pertains particularly to LC-MS proteomic analysis: sample preparation, instrumental set up and analysis, peptide identification and protein relative abundance quantitation. We also briefly describe some of the advantages, limitations and insights into the brain that can be obtained using combined proteomic and transcriptomic maps.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.