ReviewMolecular brain2009
Basic mechanisms for recognition and transport of synaptic cargos.
Review in Molecular brain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- IGF-like growth factors that couple food sensing to developmental decisions employ different release mechanisms in a single pair ofbioRxiv : the preprint server for biology · 2026Article
- Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.Developmental neurobiology · 2025Article
- Understanding the molecular diversity of synapses.Nature reviews. Neuroscience · 2025Review
- Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs.Frontiers in neural circuits · 2024Article
- Article
- Choreographing the motor-driven endosomal dance.Journal of cell science · 2023Review
- Cytoskeletal regulation guides neuronal trafficking to effectively supply the synapse.Current biology : CB · 2021Review
- Resolving cargo-motor-track interactions with bifocal parallax single-particle tracking.Biophysical journal · 2021Article
- Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation.Frontiers in molecular neuroscience · 2021Article
- Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.Journal of virology · 2020Article
- Drive, filter, and stick: A protein sorting conspiracy in photoreceptors.The Journal of cell biology · 2019Article
- FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.The Journal of cell biology · 2019Article
- Emerging Concepts and Functions of Autophagy as a Regulator of Synaptic Components and Plasticity.Cells · 2019Review
- Cyclophilin D regulates neuronal activity-induced filopodiagenesis by fine-tuning dendritic mitochondrial calcium dynamics.Journal of neurochemistry · 2018Article
- Secretory vesicle trafficking in awake and anaesthetized mice: differential speeds in axons versus synapses.The Journal of physiology · 2018Article
- Regulation of KIF1A-Driven Dense Core Vesicle Transport: CaCell reports · 2018Article
- Axonal transport deficits in multiple sclerosis: spiraling into the abyss.Acta neuropathologica · 2017Review
- A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.The Journal of cell biology · 2017Article
- Drive the Car(go)s-New Modalities to Control Cargo Trafficking in Live Cells.Frontiers in molecular neuroscience · 2017Review
- Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic vesicle precursors, mitochondria, neurotransmitter receptors and signaling proteins to their site of action, neurons make use of molecular motor proteins. These motors operate on the microtubule and actin cytoskeleton and are highly regulated so that different cargos can be transported to distinct synaptic specializations at both pre- and post-synaptic sites. How synaptic cargos achieve specificity, directionality and timing of transport is a developing area of investigation. Recent studies demonstrate that the docking of motors to their cargos is a key control point. Moreover, precise spatial and temporal regulation of motor-cargo interactions is important for transport specificity and cargo recruitment. Local signaling pathways Ca2+ influx, CaMKII signaling and Rab GTPase activity regulate motor activity and cargo release at synaptic locations. We discuss here how different motors recognize their synaptic cargo and how motor-cargo interactions are regulated by neuronal activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.