ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2009
Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- The Mediating Role of Social and Environmental Determinants of Health in the Association Between Race and Preterm Birth Risk.Journal of women's health (2002) · 2025Article
- Genome-wide association study of preterm birth and gestational age in a Japanese population.Human genome variation · 2023Article
- Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth.BMJ open · 2022Article
- Maternal biological age assessed in early pregnancy is associated with gestational age at birth.Scientific reports · 2021Article
- Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.Epigenetics · 2020Article
- Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2.PLoS genetics · 2019Article
- Spontaneous premature birth as a target of genomic research.Pediatric research · 2019Review
- Noninvasive blood tests for fetal development predict gestational age and preterm delivery.Science (New York, N.Y.) · 2018Observational
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM).Molecular genetics & genomic medicine · 2017Article
- Time-Variant Genetic Effects as a Cause for Preterm Birth: Insights from a Population of Maternal Cousins in Sweden.G3 (Bethesda, Md.) · 2017Article
- Article
- A narrow heritability evaluation of gestational age at birth.Human genetics · 2015Article
- Methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth.Translational pediatrics · 2015Article
- Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes.PloS one · 2015Article
- Resolving the effects of maternal and offspring genotype on dyadic outcomes in genome wide complex trait analysis ("M-GCTA").Behavior genetics · 2014Article
- The contribution of genetic and environmental factors to the duration of pregnancy.American journal of obstetrics and gynecology · 2014Review
- Fetal and maternal genes' influence on gestational age in a quantitative genetic analysis of 244,000 Swedish births.American journal of epidemiology · 2013Article
- Article
- The genomics of preterm birth: from animal models to human studies.Genome medicine · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The analysis of genetic and environmental contributions to preterm birth is not straightforward in family studies, as etiology could involve both maternal and fetal genes. Markov Chain Monte Carlo (MCMC) methods are presented as a flexible approach for defining user-specified covariance structures to handle multiple random effects and hierarchical dependencies inherent in children of twin (COT) studies of pregnancy outcomes. The proposed method is easily modified to allow for the study of gestational age as a continuous trait and as a binary outcome reflecting the presence or absence of preterm birth. Estimation of fetal and maternal genetic factors and the effect of the environment are demonstrated using MCMC methods implemented in WinBUGS and maximum likelihood methods in a Virginia COT sample comprising 7,061 births. In summary, although the contribution of maternal and fetal genetic factors was supported using both outcomes, additional births and/or extended relationships are required to precisely estimate both genetic effects simultaneously. We anticipate the flexibility of MCMC methods to handle increasingly complex models to be of particular relevance for the study of birth outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.